{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:55:57Z","timestamp":1790736957714,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2024,8,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cobalt complexes exhibit versatile reactivity with nitric oxide (NO), enabling their utilization in applications ranging from homogeneous catalysis to NO\u2010based modulation of biological processes. However, the coordination geometry around the cobalt center is complex, the therapeutic window of NO is narrow, and controlled NO delivery is difficult. To better understand the complexation of cobalt with NO, we prepared four cobalt nitrato complexes and present a structure\u2010property relationship for ultrasound\u2010triggerable NO release. We hypothesized that modulation of the coordination geometry by ligand\u2010modification would improve responsiveness to mechanical stimuli, like ultrasound. To enable eventual therapeutic testing, we here first demonstrate the in\u2005vitro tolerability of [Co(ethylenediamine)\n                    <jats:sub>2<\/jats:sub>\n                    (NO)(NO\n                    <jats:sub>3<\/jats:sub>\n                    )](NO\n                    <jats:sub>3<\/jats:sub>\n                    ) in A431 epidermoid carcinoma cells and J774A.1 murine macrophages, and we subsequently show successful encapsulation of the complex in poly(butyl cyanoacrylate) microbubbles. These hybrid Co\u2010NO\u2010containing microbubbles may in the future aid in ultrasound imaging\u2010guided treatment of NO\u2010responsive vascular pathologies.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202400232","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T08:44:01Z","timestamp":1715762641000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Microbubble\u2010encapsulated Cobalt Nitrato Complexes for Ultrasound\u2010triggerable Nitric Oxide Delivery"],"prefix":"10.1002","volume":"19","author":[{"given":"Patrick","family":"Koczera","sequence":"first","affiliation":[{"name":"Institute for Experimental Molecular Imaging Medical Faculty RWTH Aachen University  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Thomas","sequence":"additional","affiliation":[{"name":"Institute of Inorganic Chemistry RWTH Aachen University 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