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The lack of a universal tumor biomarker limits the therapeutic potential of these approaches. However, one feature characteristic of nearly all solid tumors is extracellular acidity. This inherent acidity provides the basis for targeted drug delivery via the pH\u2010low insertion peptide (pHLIP), which selectively accumulates in tumors in\u2005vivo due to a pH\u2010dependent membrane insertion propensity. Previously, we established that we could selectively decorate cancer cells with antigen\u2010pHLIP conjugates to facilitate antibody recruitment and subsequent killing by engineered effector cells via antibody\u2010dependent cellular cytotoxicity (ADCC). Here, we present a novel strategy for opsonizing antibodies on target cell surfaces using click chemistry. We utilize pHLIP to facilitate selective tetrazine \u2010 trans\u2010cyclooctene ligation of human IgGs to the cancer cell surface and induce ADCC. 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