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Antibacterial potential was checked against two Gram positive (\n                    <jats:italic>B. subtilis<\/jats:italic>\n                    and\n                    <jats:italic>S. aureus<\/jats:italic>\n                    ) and two Gram negative (\n                    <jats:italic>E. coli<\/jats:italic>\n                    and\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    ) bacterial strains while antifungal potential was assayed against two fungal strains (\n                    <jats:italic>C. albicans<\/jats:italic>\n                    and\n                    <jats:italic>A. niger<\/jats:italic>\n                    ). All the tested compounds showed satisfactory antibacterial potency in comparison to reference drug ciprofloxacin with MIC values ranging from 0.0108 to 0.0432\u2005\u03bcmol\/mL. Interestingly, except two, all the target compounds showed better antifungal property as compared to the reference drug fluconazole with MIC values less than 0.0408\u2005\u03bcmol\/mL. One of the compounds exhibited two\u2010fold better antifungal potential in comparison to fluconazole. Furthermore,\n                    <jats:italic>in\u2010silico<\/jats:italic>\n                    ADMET and DFT studies reported drug likeness behavior and chemical reactivity parameters, respectively. The cytotoxicity results on substrate azide\n                    <jats:bold>3<\/jats:bold>\n                    and most potent 1,2,3\u2010triazoles (\n                    <jats:bold>5\u2009d<\/jats:bold>\n                    and\n                    <jats:bold>5\u2009l<\/jats:bold>\n                    ) were found to be non\u2010toxic.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202400451","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T01:54:06Z","timestamp":1724032446000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Two Step One\u2010Pot Synthesis of 7\u2010Azaindole Linked 1,2,3\u2010Triazole Hybrids:\n                    <i>In\u2010Vitro<\/i>\n                    and\n                    <i>In\u2010Silico<\/i>\n                    Antimicrobial Evaluation"],"prefix":"10.1002","volume":"19","author":[{"given":"Kanika","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Chemistry National Institute of Technology  Kurukshetra 136119, Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bajrang","family":"Lal","sequence":"additional","affiliation":[{"name":"Department of Chemistry National Institute of Technology  Kurukshetra 136119, Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4260-0744","authenticated-orcid":false,"given":"Ram","family":"Kumar Tittal","sequence":"additional","affiliation":[{"name":"Department of Chemistry National Institute of Technology  Kurukshetra 136119, Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1996-9738","authenticated-orcid":false,"given":"Kashmiri","family":"Lal","sequence":"additional","affiliation":[{"name":"Department of Chemistry GJUS&amp;T  Hisar 12500, Haryana India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalit","family":"Vats","sequence":"additional","affiliation":[{"name":"Department of Chemistry Government College Bherian  Pehowa, Kurukshetra 136128, Hr India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0967-7777","authenticated-orcid":false,"given":"Ghule","family":"Vikas D","sequence":"additional","affiliation":[{"name":"Department of Chemistry National Institute of Technology  Kurukshetra 136119, Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202300673"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202000164"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/10406638.2022.2069133"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S234610"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2702.1998.00181.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7884316"},{"key":"e_1_2_8_7_1","first-page":"1","volume":"28","author":"Parums D. 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