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A ruthenium(IV) uracil Schiff base compound, <jats:italic>trans<\/jats:italic>\u2010[Ru(urpda)(PPh<jats:sub>3<\/jats:sub>)Cl<jats:sub>2<\/jats:sub>] (<jats:bold>6<\/jats:bold>) was also formed. Various physicochemical techniques were utilized to characterize the novel ruthenium compounds. Similarly, the stabilities of <jats:bold>1<\/jats:bold>\u2013<jats:bold>3<\/jats:bold> and <jats:bold>6<\/jats:bold> monitored in chloro\u2010containing and the non\u2010coordinating solvent, dichloromethane show that they are kinetically inert, whereas, in a high nucleophilic environment, the chloride co\u2010ligands of these ruthenium complexes were rapidly substituted by DMSO. In contrast, the substitution of the labile co\u2010ligands for these ruthenium complexes by DMSO molecules in a high chloride content was suppressed. Solution chemical reactivities of the different ruthenium complexes were rationalized by density functional theory computations. Furthermore, the binding affinities and strengths between BSA and the respective ruthenium complexes were monitored using fluorescence spectroscopy. In addition, the <jats:italic>in\u2005vitro<\/jats:italic> anti\u2010diabetic activities of the novel metal complexes were assessed in selected skeletal muscle and liver cell lines.<\/jats:p>","DOI":"10.1002\/cmdc.202400477","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T11:02:30Z","timestamp":1723546950000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Anti\u2010Amyloid Aggregation and Anti\u2010Hyperglycemic Activities of Novel Ruthenium Uracil Schiff Base Compounds"],"prefix":"10.1002","volume":"19","author":[{"given":"Daniel M.","family":"Makanyane","sequence":"first","affiliation":[{"name":"School of Chemistry and Physics University of KwaZulu-Natal  Pietermaritzburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindokuhle P.","family":"Mabuza","sequence":"additional","affiliation":[{"name":"School of Laboratory Medicine and Medical Sciences University of KwaZulu-Natal  Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phikelelani","family":"Ngubane","sequence":"additional","affiliation":[{"name":"School of Laboratory Medicine and Medical Sciences University of KwaZulu-Natal  Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andile","family":"Khathi","sequence":"additional","affiliation":[{"name":"School of Laboratory Medicine and Medical Sciences University of KwaZulu-Natal  Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen","family":"Mambanda","sequence":"additional","affiliation":[{"name":"School of Chemistry and Physics University of KwaZulu-Natal  Pietermaritzburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9680-5978","authenticated-orcid":false,"given":"Irvin N.","family":"Booysen","sequence":"additional","affiliation":[{"name":"School of Chemistry and Physics University of KwaZulu-Natal  Pietermaritzburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,9]]},"reference":[{"key":"e_1_2_8_1_1","unstructured":"\u00a0"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00141.2019"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/0145721715607642"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-021-00573-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871527313666140917095514"},{"key":"e_1_2_8_6_1","unstructured":"\u00a0"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25051195"},{"key":"e_1_2_8_7_3","first-page":"1873","volume":"10","author":"Jeong H. 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