{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:36:59Z","timestamp":1789677419103,"version":"4.0.1"},"reference-count":76,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T00:00:00Z","timestamp":1733443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2025,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A series of 2\u2010nitroimidazole\u20101,2,3\u2010triazole sulfonamide hybrid analogs were designed using medicinal chemistry approaches, such as bioisosterism, molecular hybridization, Topliss tree decision, and Craig plot. A total of 24 compounds were synthesized via click chemistry in satisfactory yields. Overall, analogs <jats:bold>15\u2009a\u2010x<\/jats:bold> exhibited relevant in\u2005vitro anti\u2010trypanosomatid activity against amastigote forms of <jats:italic>T. cruzi<\/jats:italic> and without cytotoxic effect on LLC\u2013MK2 cells. Analogs <jats:bold>15\u2009b<\/jats:bold> (R<jats:sub>1<\/jats:sub>=4\u2010Cl\u2212Ph; IC<jats:sub>50<\/jats:sub>=1.63\u2005\u03bcM, SI=&gt;30.65), <jats:bold>15\u2009m<\/jats:bold> (R<jats:sub>1<\/jats:sub>=3,4\u2010<jats:italic>di<\/jats:italic>\u2010Cl\u2212Ph; IC<jats:sub>50<\/jats:sub>=0.63\u2005\u03bcM, SI=&gt;78.96), and <jats:bold>15\u2009s<\/jats:bold> (R<jats:sub>1<\/jats:sub>=Ph\u20104\u2010O\u2212Ph; IC<jats:sub>50<\/jats:sub>=0.63\u2005\u03bcM, SI=&gt;79.90) demonstrated pronounced antitrypanosomal activity, more active than the reference drug, benznidazole and with good selectivity indexes. Furthermore, analog <jats:bold>15\u2009b<\/jats:bold> (R<jats:sub>1<\/jats:sub>=4\u2010Cl\u2212Ph; IC<jats:sub>50<\/jats:sub>=0.5\u2005\u03bcM, SI=&gt;100) exhibited an outstanding antileishmanial activity against amastigote forms of <jats:italic>Leishmania (L.) amazonensis<\/jats:italic> and impressive selectivity index, comparable to the reference compound amphotericin B. The mutagenicity of compounds <jats:bold>15\u2009b<\/jats:bold> and <jats:bold>15\u2009m<\/jats:bold> were evaluated against Salmonella typhimurium strains (TA98, TA100 and TA102). Compound <jats:bold>15\u2009b<\/jats:bold> exhibited mutageniticy only at a concentration of 500\u2005\u2009\u03bcg\/plate for the TA100 strain, whereas compound <jats:bold>15\u2009m<\/jats:bold> was considered non\u2010mutagenic. These findings suggest that 2\u2010nitroimidazoles\u20101,2,3\u2010triazole sulfonamide hybrid analogs are promising anti\u2010trypanosomatid candidates for future in\u2005vivo studies.<\/jats:p>","DOI":"10.1002\/cmdc.202400516","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T11:58:49Z","timestamp":1732103929000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Design and Synthesis of 2\u2010Nitroimidazole\u20101,2,3\u2010triazole Sulfonamide Hybrids as Potent and Selective Anti\u2010Trypanosomatid Agents"],"prefix":"10.1002","volume":"20","author":[{"given":"Vict\u00f3ria C.","family":"Tietz","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de S\u00edntese e Qu\u00edmica Medicinal (LASQUIM). 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