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In this work, we investigated the impacts of Cyanine 5.5 and Doxorubicin on cell cycle arrest, magnetic resonance, and NIR fluorescence optical imaging for Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>\u2010encapsulated nanosystems based on poly(lactide)\u2010tocopheryl polyethylene glycol succinate (PLA\u2010TPGS) copolymer. Although Cyanine 5.5 and Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> nanoparticles (NPs) are less cytotoxic than Doxorubicin, they present a cytostatic effect, inducing cell cycle arrest at the G2\/M phase in human brain adenocarcinoma (CCF\u2010STTG1) cells. For MRI applications, the permeability of the PLA\u2010TPGS copolymer coating layer to water molecules might lengthen the translational diffusion time (\n), causing the higher relaxivity ratio (r<jats:sub>2<\/jats:sub>\/r<jats:sub>1<\/jats:sub>) compared to bare Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> NPs under an applied magnetic field (7 Tesla). Notably, the chemical structures of Cyanine 5.5 and Doxorubicin significantly contribute to the enhancement of the T<jats:sub>2<\/jats:sub> relaxivities of Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> NPs through \u03c0\u2010\u03c0 and \u03c1\u2010\u03c0 conjugation. Furthermore, the radiance ratio and signal\u2010to\u2010noise ratio enhancement and a slight blue shift in the optimal excitation and emission wavelengths were recorded. These findings show the potential for <jats:italic>in\u2005vivo<\/jats:italic> MRI and NIR bioimaging experiments of the nanoparticles.<\/jats:p>","DOI":"10.1002\/cmdc.202400586","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:30:23Z","timestamp":1732149023000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Influence of Cyanine 5.5 and Doxorubicin on Cell Cycle Arrest, Magnetic Resonance, and Near\u2010Infrared Fluorescence Optical Imaging for Fe<sub>3<\/sub>O<sub>4<\/sub>\u2010Encapsulated PLA\u2010TPGS Nanoparticles"],"prefix":"10.1002","volume":"20","author":[{"given":"Ke","family":"Son Phan","sequence":"first","affiliation":[{"name":"Institute of Materials Science Vietnam Academy of Science and Technology  18 Hoang Quoc Viet Road, Cau Giay District Hanoi Vietnam"},{"name":"Graduate University of Science and Technology Vietnam Academy of Science and Technology  18 Hoang Quoc Viet Road, Cau Giay District Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huu","family":"Nghi Do","sequence":"additional","affiliation":[{"name":"Institute of Natural Products Chemistry Vietnam Academy of Science and Technology  18 Hoang Quoc Viet Road, Cau Giay District Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bich","family":"Thuy Doan","sequence":"additional","affiliation":[{"name":"The Institute I\u2013CLeHS Institute of Chemistry for Life and Health Sciences ENSCP Chimie ParisTech PSL Universit\u00e9, CNRS UMR  8060 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi","family":"Thu Huong Le","sequence":"additional","affiliation":[{"name":"Faculty of Natural Resources and Environment Vietnam National University of Agriculture, Trau Quy, Gia Lam District  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi","family":"Thu Trang Mai","sequence":"additional","affiliation":[{"name":"Institute of Materials Science Vietnam Academy of Science and Technology  18 Hoang Quoc Viet Road, Cau Giay District Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quynh","family":"Bao Ngoc Nguyen","sequence":"additional","affiliation":[{"name":"Institute of Materials Science Vietnam Academy of Science and Technology  18 Hoang Quoc Viet Road, Cau Giay District Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi","family":"Nham Dong","sequence":"additional","affiliation":[{"name":"Institute of Materials Science Vietnam Academy of Science and Technology  18 Hoang Quoc Viet Road, Cau Giay District Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0317-4068","authenticated-orcid":false,"given":"Bao","family":"Hung Bui Ha","sequence":"additional","affiliation":[{"name":"Institute of Materials Science Vietnam Academy of Science and Technology  18 Hoang Quoc Viet Road, Cau Giay District Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viet","family":"Dung Dang","sequence":"additional","affiliation":[{"name":"Institute of Materials Science Vietnam Academy of Science and Technology  18 Hoang Quoc Viet Road, Cau Giay District Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le Hang","family":"Dang","sequence":"additional","affiliation":[{"name":"Institute of Applied Materials Science Vietnam Academy of Science and Technology, HCMC  VietNam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngoc","family":"Quyen Tran","sequence":"additional","affiliation":[{"name":"Institute of Applied Materials Science Vietnam Academy of Science and Technology, HCMC  VietNam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuong","family":"Thu Ha","sequence":"additional","affiliation":[{"name":"Institute of Materials Science Vietnam Academy of Science and Technology  18 Hoang Quoc Viet Road, Cau Giay District Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,3]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.3390\/app112311301"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.1c00440"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsadv.2021.100163"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114505"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.01.009"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5TB00789E"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.7b00253"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","unstructured":"D. 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