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The resulting compounds were obtained in moderate to good yields. All the newly synthesized compounds were evaluated for their antimicrobial activity. Among them, compound <jats:bold>4\u2009e<\/jats:bold> demonstrated superior efficacy against the <jats:italic>Salinivibrio proteolyticus<\/jats:italic> strain of Gram\u2010negative bacteria compared to ciprofloxacin. Compound <jats:bold>4\u2009d<\/jats:bold> exhibited the highest potency against the fungal strain <jats:italic>Candida albicans<\/jats:italic>, surpassing amphotericin B. The physicochemical characteristics of <jats:bold>4\u2009d<\/jats:bold> and <jats:bold>4\u2009e<\/jats:bold> were assessed. According to docking analysis, DHTDAPy <jats:bold>4\u2009e<\/jats:bold> shows a higher binding affinity of \u22127.2\u2005kcal\/mol in the binding cavity of the receptor. These findings illustrate the safety, tolerability, and potency of the newly synthesized DHTDAPy compounds against fungal and bacterial infections.<\/jats:p>","DOI":"10.1002\/cmdc.202400595","type":"journal-article","created":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T14:23:30Z","timestamp":1728743010000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Acetic Acid\u2010Driven One\u2010Pot Synthesis of 4,7\u2010dihydro\u2010[1,2,3]thiadiazolo[5,4\u2010<i>b<\/i>]pyridine\u20106\u2010carboxamides and Pharmacological Evaluations"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2456-7951","authenticated-orcid":false,"given":"Savan S","family":"Bhalodiya","sequence":"first","affiliation":[{"name":"Department of Chemistry Sardar Patel University  Vallabh Vidyanagar 388120 Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6958-8568","authenticated-orcid":false,"given":"Mehul P.","family":"Parmar","sequence":"additional","affiliation":[{"name":"Department of Chemistry Sardar Patel University  Vallabh Vidyanagar 388120 Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1786-3475","authenticated-orcid":false,"given":"Chirag D.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Chemistry Sardar Patel University  Vallabh Vidyanagar 388120 Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2203-4127","authenticated-orcid":false,"given":"Subham G.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Chemistry Sardar Patel University  Vallabh Vidyanagar 388120 Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6979-3657","authenticated-orcid":false,"given":"Disha P.","family":"Vala","sequence":"additional","affiliation":[{"name":"Department of Chemistry Sardar Patel University  Vallabh Vidyanagar 388120 Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7731-6278","authenticated-orcid":false,"given":"Nandhakumar","family":"Suresh","sequence":"additional","affiliation":[{"name":"Cancer biology lab Center for Molecular and Nanomedical Sciences Sathyabama Institute of Science and Technology  Chennai, Tamil Nadu 600119 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3141-4836","authenticated-orcid":false,"given":"Bhuvaneshwari","family":"Jayachandran","sequence":"additional","affiliation":[{"name":"Cancer biology lab Center for Molecular and Nanomedical Sciences Sathyabama Institute of Science and Technology  Chennai, Tamil Nadu 600119 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0567-7857","authenticated-orcid":false,"given":"Madan","family":"Kumar Arumugam","sequence":"additional","affiliation":[{"name":"Cancer biology lab Center for Molecular and Nanomedical Sciences Sathyabama Institute of Science and Technology  Chennai, Tamil Nadu 600119 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2194-5228","authenticated-orcid":false,"given":"Mahesh","family":"Narayan","sequence":"additional","affiliation":[{"name":"Biochemistry Division Department of Chemistry and Biochemistry, CCSB 2.0202 University of Texas at El Paso 500\u2005W. 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