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The newly obtained compounds demonstrated remarkable inhibition potency and selectivity for the human (h) expressed Carbonic Anhydrase (CA; EC 4.2.1.1) II isoform. Selected compounds <jats:bold>7<\/jats:bold> and <jats:bold>9<\/jats:bold> were investigated in an <jats:italic>in\u2005vivo<\/jats:italic> model of glaucoma and showed relevant performances, with the latter being able to last the effect up to 4\u2005hours. 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