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With a diameter of 5\u20137\u2005nm, the spherical nanomaterial is made of manganese oxide and citrate. Here, we have produced the novel nanomaterial and, using cutting\u2010edge electron microscopic and spectroscopic techniques, extensively assessed its redox buffering potential <jats:italic>in vitro<\/jats:italic> with its structural integrity. Using an appropriate animal model (Phenylhydrazine, PHz, intoxicated C57BL\/6J mice), we assessed the therapeutic efficacy of the redox buffering nanomedicine in the treatment of anemia and related consequences. We have further investigated the intricate molecular mechanism of the nanomedicine and its therapeutic impact, which includes increased erythropoiesis and G6PDH production, decreased inflammatory responses, mitigation of splenic hyperplasia, and synergistic intracellular redox buffering. To the best of our knowledge, our studies would find relevance in the innovative management of anemia, decreased erythropoiesis, and splenic hyperplasia.<\/jats:p>","DOI":"10.1002\/cmdc.202400698","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T03:49:37Z","timestamp":1731642577000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Pleiotropic Nanomedicine Mitigates Splenic Hyperplasia, Ineffective Erythropoiesis, G6PDH Anomaly through Redox Buffering in Preclinical Mice Model"],"prefix":"10.1002","volume":"20","author":[{"given":"Monojit","family":"Das","sequence":"first","affiliation":[{"name":"Department of Zoology Vidyasagar University  Rangamati, Midnapore 721102 India"},{"name":"Department of Zoology Uluberia College University of Calcutta  Uluberia, Howrah 711315 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susmita","family":"Mondal","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Sciences S. N. Bose National Centre for Basic Sciences  Block JD, Sector 3, Salt Lake Kolkata 700106 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ria","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Sciences S. N. Bose National Centre for Basic Sciences  Block JD, Sector 3, Salt Lake Kolkata 700106 India"},{"name":"Department of Biochemistry University of Calcutta  35, Ballygunge Circular Road Kolkata 700019 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lopamudra","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Applied Optics and Photonics University of Calcutta  JD-2, Sector-III, Salt Lake Kolkata West Bengal 700 106 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjan","family":"Kumar Das","sequence":"additional","affiliation":[{"name":"Department of Pathology Coochbehar Government Medical College and Hospital  Kotwali, Coochbehar 736101 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddhartha","family":"Sankar Bhattacharya","sequence":"additional","affiliation":[{"name":"Department of Zoology Uluberia College University of Calcutta  Uluberia, Howrah 711315 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6943-5828","authenticated-orcid":false,"given":"Debasish","family":"Pal","sequence":"additional","affiliation":[{"name":"Department of Zoology Uluberia College University of Calcutta  Uluberia, Howrah 711315 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debasish","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Department of Gynecology &amp; Obstetrics Nil Ratan Sircar Medical College and Hospital  Kolkata 700014 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prantar","family":"Chakrabarti","sequence":"additional","affiliation":[{"name":"Department of Hematology Vivekananda Institute of Medical Sciences  Kolkata 700026 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asim","family":"Kumar Mallick","sequence":"additional","affiliation":[{"name":"Department of Pediatric Medicine Nil Ratan Sircar Medical College and Hospital  Kolkata 700014 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayanta","family":"Kumar Kundu","sequence":"additional","affiliation":[{"name":"Department of Zoology Vidyasagar University  Rangamati, Midnapore 721102 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Kumar Pal","sequence":"additional","affiliation":[{"name":"Department of Zoology Uluberia College University of Calcutta  Uluberia, Howrah 711315 India"},{"name":"Department of Chemical and Biological Sciences S. 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