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A combination of light\u2010controlled chemotherapy (PACT) and photodynamic therapy (PDT) in one molecule has the potential to overcome crucial drawbacks of both Pt\u2010based chemotherapy and PDT via a synergetic effect. Herein we report green\u2010light\u2010activated Pt(IV) prodrug\n                    <jats:bold>GreenPt<\/jats:bold>\n                    with BODIPY\u2010based photosentitizer in the axial position with an incredible high light response and singlet oxygen generation ability.\n                    <jats:bold>GreenPt<\/jats:bold>\n                    demonstrated the ability to release cisplatin under low\u2010dose green light irradiation up to 1\u2005J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    . The investigation of the photoreduction mechanism of\n                    <jats:bold>GreenPt<\/jats:bold>\n                    prodrug using DFT modeling and \u0394G\n                    <jats:sub>0<\/jats:sub>\n                    PET estimation revealed that the anion\u2010radical formation and substituent photoinduced electron transfer from the triplet excited state of the BODIPY axial ligand to the Pt(IV) center is the key step in the light\u2010induced release of cisplatin. Green\u2010light\u2010activated BODIPY\u2010based photosentitizers\n                    <jats:bold>5<\/jats:bold>\n                    and\n                    <jats:bold>8<\/jats:bold>\n                    demonstrated outstanding photosensitizing properties with an extraordinary phototoxicity index (PI)&gt;1300.\n                    <jats:bold>GreenPt<\/jats:bold>\n                    prodrug demonstrated gradual intracellular accumulation and light\u2010induced phototoxicity with PI&gt;100, thus demonstrating dual action through light\u2010controlled release of both cisplatin and a potent BODIPY\u2010based photosensitizer.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202400786","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T04:25:57Z","timestamp":1736483157000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Green Light Activated Dual\u2010Action Pt(IV) Prodrug with Enhanced PDT Activity"],"prefix":"10.1002","volume":"20","author":[{"given":"Daniil","family":"Spector","sequence":"first","affiliation":[{"name":"Chemistry Department Lomonosov Moscow State University  Leninskie gory 1,3 119991 Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladislav","family":"Bykusov","sequence":"additional","affiliation":[{"name":"Chemistry Department Lomonosov Moscow State University  Leninskie gory 1,3 119991 Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia","family":"Isaeva","sequence":"additional","affiliation":[{"name":"I.M. 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