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This study describes the solid\u2010phase synthesis of octadentate Zr\u2010chelators based on an isopeptidic (ip) scaffold derived from the natural siderophore desferrioxamine (DFOB). Several analogues with different spacers separating the chelating hydroxamates have been prepared and converted to [<jats:sup>89<\/jats:sup>Zr]Zr\u2010complexes. The stability of these complexes was evaluated in human serum and in competition to excess of competing chelators. The assays revealed a beneficial effect of long hydroxamate spacing (9 atoms). Shorter spacing led to a decrease in complex stability. The most stable [<jats:sup>89<\/jats:sup>Zr]Zr\u2010ipDFO complex had a high stability in challenging competition experiments with a large excess of EDTA for 72\u2005h as determined by radio TLC and LC\/MS. The straightforward synthesis, high complex stability and a modular character make ipDFO derivatives promising chelators for applications in targeted PET.<\/jats:p>","DOI":"10.1002\/cmdc.202400890","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T04:25:40Z","timestamp":1733804740000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Isopeptidic Desferrioxamine Analogues: The Role of Hydroxamate Spacing for Chelation of Zr<sup>4+<\/sup>"],"prefix":"10.1002","volume":"20","author":[{"given":"Lasse","family":"Outzen","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Hamburg  Bundesstrasse 45 20146 Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darius","family":"Ludolfs","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Hamburg  Bundesstrasse 45 20146 Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Irl","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine School of Medicine TUM University Hospital and Central Institute for Translational Cancer Research (TranslaTUM) Technical University Munich  Ismaninger Stra\u00dfe 22 81675 Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Kossatz","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine School of Medicine TUM University Hospital and Central Institute for Translational Cancer Research (TranslaTUM) Technical University Munich  Ismaninger Stra\u00dfe 22 81675 Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2793-5722","authenticated-orcid":false,"given":"Wolfgang","family":"Maison","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Hamburg  Bundesstrasse 45 20146 Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,23]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23095023"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200800222"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21124309"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.9b00738"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7DT01936J"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-021-05661-0"},{"key":"e_1_2_8_7_1","first-page":"1271","volume":"44","author":"Verel I.","year":"2003","journal-title":"J. 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