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However, most degraders rely on a small number of E3 ligases. In this study, we present the first\u2010in\u2010class histone deacetylase (HDAC) PROTACs recruiting the DDB1\u2010 and CUL4\u2010 associated factor 11 (DCAF11). We established a synthesis route entirely on solid\u2010phase to prepare a set of eleven degraders. The long and flexible spacer bearing\n                    <jats:bold>FF2039<\/jats:bold>\n                    (\n                    <jats:bold>1j<\/jats:bold>\n                    ) showed significant HDAC1 and 6 degradation in combination with cytotoxicity against the multiple myeloma cell line MM.1S. Further investigations revealed that\n                    <jats:bold>1j<\/jats:bold>\n                    was also able to degrade HDAC isoforms of class I, IIa and IIb. Compared to our previously published cereblon\u2010recruiting HDAC6 selective PROTAC\n                    <jats:bold>A6<\/jats:bold>\n                    , we succesfully transformed the selective degrader into a pan\u2010HDAC degrader by switching the recruited E3 ligase. A detailed profiling of the anticancer properties of\n                    <jats:bold>1j<\/jats:bold>\n                    demonstrated its significant antiproliferative activity against both hematological and solid cancer cell lines, driven by cell cycle arrest and apoptosis induction.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202500035","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T03:11:27Z","timestamp":1740021087000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Replacing a Cereblon Ligand by a DDB1 and CUL4 Associated Factor 11 (DCAF11) Recruiter Converts a Selective Histone Deacetylase 6 PROTAC into a Pan\u2010Degrader"],"prefix":"10.1002","volume":"20","author":[{"given":"Felix","family":"Feller","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical and Cell Biological Chemistry Pharmaceutical Institute University of Bonn  An der Immenburg 4 53121 Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Cell Biological Chemistry Pharmaceutical Institute University of Bonn  An der Immenburg 4 53121 Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Miranda","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Cell Biological Chemistry Pharmaceutical Institute University of Bonn  An der Immenburg 4 53121 Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Honin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Cell Biological Chemistry Pharmaceutical Institute University of Bonn  An der Immenburg 4 53121 Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Hanl","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Cell Biological Chemistry Pharmaceutical Institute University of Bonn  An der Immenburg 4 53121 Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9765-5975","authenticated-orcid":false,"given":"Finn K.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Cell Biological Chemistry Pharmaceutical Institute University of Bonn  An der Immenburg 4 53121 Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,24]]},"reference":[{"key":"e_1_2_8_1_1","unstructured":"J. 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