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The main symptoms of O'nyong\u2010nyong fever are nonspecific and flu like; a proper diagnosis at the early stage is challenging. Until today, the first ONNV epidemic in 1959\u20131962 remains one of the largest arbovirus outbreaks ever recorded (over 2 million cases). No specific therapy is available thus far. Capsid protease (CP) is a chymotrypsin\u2010like serine protease that catalyzes the autoproteolytic maturation of the structural polyprotein and undergoes self\u2010inactivation upon the release of the mature capsid (C) protein. Despite the discovery of this virus more than 60\u2009years ago, many aspects of CP remain understudied, including substrate specificity. Herein, the structures of the first phosphonic\u2010type inhibitors and activity\u2010based probes specific to the ONNV CP are presented.<\/jats:p>","DOI":"10.1002\/cmdc.202500049","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T17:05:38Z","timestamp":1744045538000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["First Phosphonic\u2010Type Inhibitors and Activity\u2010Based Probes Specific to the O'nyong\u2010nyong Virus Capsid Protease"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3432-2529","authenticated-orcid":false,"given":"Karolina","family":"Torzyk\u2010Jurowska","sequence":"first","affiliation":[{"name":"Division of Organic and Medicinal Chemistry Faculty of Chemistry Wroclaw University of Science and Technology  Wybrzeze Wyspianskiego 27 50\u2010370 Wroclaw 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