{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T02:58:30Z","timestamp":1781578710480,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2025,7,18]]},"abstract":"<jats:p>This study reports the design and synthesis of benzofuran\u2010tethered sulfamoyl triazoles. These compounds are evaluated against two human carbonic anhydrases (hCA I and II) and three CAs from the bacterial pathogen mycobacterium TB (mtCA1\u20133). The findings indicate that molecules featuring triazolyl benzene\u20103\u2010sulfonamide are significantly more selective for mtCA 1\u20133 than hCA I and II. In contrast, across the generated molecules, benzofuran with triazolyl benzene\u20104\u2010sulfonamide demonstrates greater selectivity for hCA II than mtCAs. Among these compounds, <jats:bold>3F4<\/jats:bold> shows the greatest suppression of mtCA2, with a Ki value of 0.0052\u2009\u03bcM. <jats:bold>4F1<\/jats:bold> demonstrates essential and focused inhibition of hCA II, with a Ki value of 0.0094\u2009\u03bcM. Compound <jats:bold>3F4<\/jats:bold> is 439 times more selective to mtCA2 than hCA I and 47 times more selective than hCAII. Additionally, when examined for antitubercular activity, these compounds show minimum inhibitory concentration values for Mtb H37Rv strain inhibition in the range of moderate to good with 4\u2013128\u2009\u03bcg\u2009mL<jats:sup>\u22121<\/jats:sup>.<\/jats:p>","DOI":"10.1002\/cmdc.202500080","type":"journal-article","created":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T05:46:36Z","timestamp":1745041596000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Exploration of 3\u2010Substituted Benzofuran\u2010Tethered Sulfamoyl Triazoles as Carbonic Anhydrase Inhibitors: Design, Synthesis, and Biological Evaluation"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1827-9131","authenticated-orcid":false,"given":"Anuradha","family":"Singampalli","sequence":"first","affiliation":[{"name":"Department of Chemical Sciences National Institute of Pharmaceutical Education and Research (NIPER)  Balanagar Hyderabad Telangana 500037 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rani","family":"Bandela","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences National Institute of Pharmaceutical Education and Research (NIPER)  Balanagar Hyderabad Telangana 500037 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bulti","family":"Bakchi","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences National Institute of Pharmaceutical Education and Research (NIPER)  Balanagar Hyderabad Telangana 500037 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0669-7481","authenticated-orcid":false,"given":"Simone","family":"Giovannuzzi","sequence":"additional","affiliation":[{"name":"Department NEUROFARBA Pharmaceutical and Nutraceutical Section University of Florence  Sesto Fiorentino 50019 Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3036-8693","authenticated-orcid":false,"given":"Karol","family":"Biernacki","sequence":"additional","affiliation":[{"name":"Department NEUROFARBA Pharmaceutical and Nutraceutical Section University of Florence  Sesto Fiorentino 50019 Florence Italy"},{"name":"Department of Organic Chemistry Faculty of Chemistry Gda\u0144sk University of Technology  80\u2010233 Gda\u0144sk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2923-9328","authenticated-orcid":false,"given":"Puja Kumari","family":"Agnivesh","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences National Institute of Pharmaceutical Education and Research (NIPER)  Balanagar Hyderabad Telangana 500037 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6671-2022","authenticated-orcid":false,"given":"Srinivas","family":"Nanduri","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences National Institute of Pharmaceutical Education and Research (NIPER)  Balanagar Hyderabad Telangana 500037 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4346-6567","authenticated-orcid":false,"given":"Nitin Pal","family":"Kalia","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences National Institute of Pharmaceutical Education and Research (NIPER)  Balanagar Hyderabad Telangana 500037 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4262-0323","authenticated-orcid":false,"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"Department NEUROFARBA Pharmaceutical and Nutraceutical Section University of Florence  Sesto Fiorentino 50019 Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9813-8694","authenticated-orcid":false,"given":"Venkata Madhavi","family":"Yaddanapudi","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences National Institute of Pharmaceutical Education and Research (NIPER)  Balanagar Hyderabad Telangana 500037 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"\u201cGlobal tuberculosis report2022\u201d can be found underhttps:\/\/www.who.int\/teams\/global\u2010programme\u2010on\u2010tuberculosis\u2010and\u2010lung\u2010health\/tb\u2010reports\/global\u2010tuberculosis\u2010report\u20102022."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm9003126"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2467"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20160115"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr200176r"},{"key":"e_1_2_8_7_1","first-page":"216","volume":"69","author":"Ozensoy O.","year":"2004","journal-title":"Biochemistry"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M510756200"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161210793429814"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2011.00034"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21713"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm9000488"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2011.641015"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2013.842233"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.864286"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11030-011-9319-0"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm2003624"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2021.127810"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm300125e"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9RA04917G"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm401326j"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909133107"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c01586"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202203333"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2022.132712"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae303"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)62326-9"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2011.650168"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2012.11.085"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.521"}],"container-title":["ChemMedChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.202500080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T17:11:23Z","timestamp":1760289083000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cmdc.202500080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,20]]},"references-count":29,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2025,7,18]]}},"alternative-id":["10.1002\/cmdc.202500080"],"URL":"https:\/\/doi.org\/10.1002\/cmdc.202500080","archive":["Portico"],"relation":{},"ISSN":["1860-7179","1860-7187"],"issn-type":[{"value":"1860-7179","type":"print"},{"value":"1860-7187","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,20]]},"assertion":[{"value":"2025-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202500080"}}