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Thirteen of the 50 compounds are identified as cytotoxic at 50\u2009\u03bcM using a traditional (48\u2010h compound exposure) assay against 7 pancreatic cancer cell lines and 1 noncancerous cell line. The potential role of the compounds as metabolic inhibitors of adenosine triphosphate (ATP) production is then evaluated using a rapid screening (1\u20132\u2009h compound exposure) assay developed within our laboratories. The rapid assay identifies ten compounds as strong or moderate hits at 3\u2009\u03bcM against the panel of pancreatic and noncancerous cell lines. The IC<jats:sub>50<\/jats:sub> values of the active compounds are determined using the rapid assay in the absence of glucose and four of the compounds display an IC<jats:sub>50<\/jats:sub> value &lt;1\u2009\u03bcM against one or more pancreatic cancer cell lines. A comparison of IC<jats:sub>50<\/jats:sub> values of the active compounds in the presence of glucose implicates the potential role of the compounds as oxidative phosphorylation inhibitors of ATP production. Finally, a series of amide analogs are synthesized and screened for activity to determine the structural importance of the sulfonamide functionality.<\/jats:p>","DOI":"10.1002\/cmdc.202500136","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T22:35:56Z","timestamp":1745879756000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Inhibition of Adenosine Triphosphate Production in Pancreatic Cancer Cells by a Library of N\u2010(1H\u2010Indol\u20104\u2010ylmethyl)benzenesulfonamide and N\u2010(1H\u2010Indol\u20105\u2010ylmethyl)benzenesulfonamide Analogs"],"prefix":"10.1002","volume":"20","author":[{"given":"Ryan C.","family":"Witt","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry The University of Tulsa  800 South Tucker Drive Tulsa OK 74104 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline 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