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Low minimal inhibitory concentration values of 0.5\u20134\u2009\u03bcg\u2009mL<jats:sup>\u22121<\/jats:sup> are found against a series of multidrug resistant bacterial strains including different <jats:italic>Staphylococcus<\/jats:italic> and <jats:italic>Enterococcus<\/jats:italic> genera species. The lead compound, which is decorated by a halogenated aryl ring system, appears to be bacteriostatic and shows excellent physicochemical and pharmacokinetic properties. 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