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However, the strong interactions of the phospholipid bilayer promote the adsorption of plasma proteins onto nanocarriers, leading to physicochemical instability and undesired aggregation. This study explores the use of polyoxyethylene alkyl ether (Brij), a PEG\u2010based surfactant, to enhance the stability of phospholipid bilayer\u2010coated MSN in serum environments. Initially, Brij\u2010coated liposome (LB), a type of phospholipid\u2010based nanoparticles, is synthesized via the thin film hydration method. The LB is subsequently immobilized onto the MSN surface to form Brij\u2010coated MSN\u2010liposome nanoparticles (MLB). The physicochemical properties and morphology of MLB are characterized through Fourier transform infrared spectroscopy, energy\u2010dispersive X\u2010ray spectroscopy, Brunauer\u2212Emmett\u2212Teller, scanning electron microscopy, transmission electron microscopy, and dynamic light scattering. The Brij\u2010coated MLB exhibited significantly improved stability in serum environments compared to MSN coated with an unmodified phospholipid bilayer. Furthermore, the influence of Brij on the loading capacity and release behavior of a poorly water\u2010soluble drug was assessed using quercetin as a model drug. Biocompatibility assessments demonstrated that MLB exhibited low cytotoxicity when tested on HeLa cells, indicating its potential for biomedical applications.<\/jats:p>","DOI":"10.1002\/cmdc.202500223","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:31:51Z","timestamp":1759883511000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Enhancing Stability and Entrapment Efficiency of Liposome\u2010Coated Mesoporous Silica Nanocarriers Using Polyoxyethylene Alkyl Ether as a Polyethylene Glycol Anchoring Agent"],"prefix":"10.1002","volume":"20","author":[{"given":"Tien\u2010Dung","family":"Nguyen\u2010Dinh","sequence":"first","affiliation":[{"name":"Institute of Advanced Technology Vietnam Academy of Science and Technology  1B TL29 Street, An Phu Dong Ward Ho Chi Minh City 700000 Vietnam"},{"name":"Graduate University of Science and Technology Vietnam Academy of Science and Technology  18 Hoang Quoc Viet, Nghia Do Ward Ha Noi 100000 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9227-8496","authenticated-orcid":false,"given":"Ngoc Hoi","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Institute of Advanced Technology Vietnam Academy of Science and Technology  1B TL29 Street, An Phu Dong Ward Ho Chi Minh City 700000 Vietnam"},{"name":"Graduate University of Science and Technology Vietnam Academy of Science and Technology  18 Hoang Quoc Viet, Nghia Do Ward Ha Noi 100000 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tan Phat","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Institute of Advanced Technology Vietnam Academy of Science and Technology  1B TL29 Street, An Phu Dong Ward Ho Chi Minh City 700000 Vietnam"},{"name":"Graduate University of Science and Technology Vietnam Academy of Science and Technology  18 Hoang Quoc Viet, Nghia Do Ward Ha Noi 100000 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngoc Thuy Trang","family":"Le","sequence":"additional","affiliation":[{"name":"Institute of Advanced Technology Vietnam Academy of Science and Technology  1B TL29 Street, An Phu Dong Ward Ho Chi Minh City 700000 Vietnam"},{"name":"Graduate University of Science and Technology Vietnam Academy of Science and Technology  18 Hoang Quoc Viet, Nghia Do Ward Ha Noi 100000 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3501-7390","authenticated-orcid":false,"given":"Dai Hai","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Institute of Advanced Technology Vietnam Academy of Science and Technology  1B TL29 Street, An Phu Dong Ward Ho Chi Minh City 700000 Vietnam"},{"name":"Graduate University of Science and Technology Vietnam Academy of Science and Technology  18 Hoang Quoc Viet, Nghia Do Ward Ha Noi 100000 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2022.130218"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.4c01608"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0TB01031F"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2022.214687"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.7b00989"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7TB02354E"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c14189"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202201884"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2017.04.059"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2024.110221"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b02819"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2022.103943"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201502119"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2022.114751"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.2c01133"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b00510"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.05.012"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.2217\/17435889.1.3.297"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.2c00283"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9NR05797H"},{"key":"e_1_2_9_22_1","first-page":"33","volume":"17","author":"Fazel M.","year":"2018","journal-title":"Iran. 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