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Traditional methods of wound healing are prone to several limitations, like infections, oxidative stress, and development of secondary wounds. Management of oxidative stress is an interesting platform to deal with chronic wounds. For this study, novel derivatives of protocatechuic acid, a naturally occurring phenolic acid, were designed by modifying the carboxylic acid moiety while preserving the hydroxyl groups for radical scavenging. So, a series of amide conjugates were synthesized by incorporating various amine moieties. Glucose conjugates were obtained through both click chemistry and direct coupling strategies and a chlorinated derivative was also prepared. The antioxidant potential of the compounds was screened using DPPH assay, followed by in vitro DCFDA assay on HEK\u2010293T cell line. Top 5 lead molecules were checked for biocompatibility through MTT assay, which provided us with top 2 leads, Compounds 12 and 17 which were examined for a wound healing study on Wistar rats along with the starting compound 1. It was observed that Compound 17 demonstrated excellent wound tissue regeneration on day 12, as compared to the control group, suggesting the promising role of triazole and glucose moieties conjugation for relieving oxidative stress and wound management.<\/jats:p>","DOI":"10.1002\/cmdc.202500280","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T16:20:09Z","timestamp":1755534009000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Protocatechuic Acid and its Derivatives: Synthesis, Antioxidant Properties, and Potential In Vivo Wound Healing Applications"],"prefix":"10.1002","volume":"20","author":[{"given":"Sumit","family":"Maurya","sequence":"first","affiliation":[{"name":"Department of Chemistry Institute of Science Banaras Hindu University  Varanasi Uttar Pradesh 221005 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Manna","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering IIT (BHU) Varanasi  Varanasi Uttar Pradesh 221005 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mala","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Chemistry Institute of Science Banaras Hindu University  Varanasi Uttar Pradesh 221005 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharmendra","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Chemistry Institute of Science Banaras Hindu University  Varanasi Uttar Pradesh 221005 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malay","family":"Nayak","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering IIT (BHU) Varanasi  Varanasi Uttar Pradesh 221005 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3625-2272","authenticated-orcid":false,"given":"Sudip","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering IIT (BHU) Varanasi  Varanasi Uttar Pradesh 221005 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6506-4864","authenticated-orcid":false,"given":"Arunava","family":"Manna","sequence":"additional","affiliation":[{"name":"Department of Chemistry Institute of Science Banaras Hindu University  Varanasi Uttar Pradesh 221005 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16155"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28020598"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-022-00377-3"},{"key":"e_1_2_8_5_1","first-page":"32268","volume":"9","author":"Zhong Y.","year":"2024","journal-title":"ACS Omega"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/acb370401"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01549-9"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15112360"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/438056"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(95)00639-Q"},{"key":"e_1_2_8_11_1","first-page":"1061","volume":"0123456789","author":"da Silva A. 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