{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:35:27Z","timestamp":1792445727241,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2025,9,11]]},"abstract":"<jats:p>\n                    This study reports the design, synthesis, and biological evaluation of 1H\u20101,2,3\u2010triazole\u2010tethered bisnaphthalimide\u2010isatin hybrids as potential antiproliferative agents. The compounds are efficiently synthesized via copper\u2010promoted azide\u2013alkyne cycloaddition and assayed against triple\u2010negative breast (MDA\u2010MB\u2010231) and prostate (DU\u2010145) cancer cell lines. Structure\u2013activity relationship studies reveal that halogen substitution and spacer length substantially influenced anticancer activity. The bisnaphthalimide\u2010isatin hybrid featuring dibromo substitution and a propyl linker demonstrates IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 3.3\u2009\u00b1\u20090.1 \u03bcM (DU\u2010145) and 4.4\u2009\u00b1\u20090.3 \u03bcM (MDA\u2010MB\u2010231), comparable to clinical drugs cisplatin and 5\u2010fluorouracil. Notably, it exhibits favorable selectivity indices (2.07\u20132.76) against cancer versus normal keratinocytes (HaCaT). Mechanistic investigations establish that it induces caspase\u2010mediated apoptosis and molecular docking studies confirmed its strong interaction with DNA topoisomerase II (docking score: \u22124.894), comparable to doxorubicin.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202500415","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T20:28:06Z","timestamp":1753734486000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Design, Synthesis, and Antiproliferative and Apoptotic Assessment of Triazole\u2010Tethered Bisnaphthalimide\u2010Isatin Hybrids on Triple\u2010Negative Breast and Prostate Cancers"],"prefix":"10.1002","volume":"20","author":[{"family":"Preeti","sequence":"first","affiliation":[{"name":"Department of Chemistry Guru Nanak Dev University  Amritsar Punjab 143005 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