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This study evaluates the patented compounds\n                    <jats:italic>meso<\/jats:italic>\n                    \u2010tris\u2010\n                    <jats:italic>p<\/jats:italic>\n                    \u2010carboxyphenyl porphyrin\u2010fullerene (P\u2010F) dyads,\n                    <jats:bold>PB<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>3<\/jats:bold>\n                    <\/jats:sub>\n                    <jats:bold>C<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>60<\/jats:bold>\n                    <\/jats:sub>\n                    and\n                    <jats:bold>PB<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>3<\/jats:bold>\n                    <\/jats:sub>\n                    <jats:bold>C<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>70<\/jats:bold>\n                    <\/jats:sub>\n                    , and precursor PB\n                    <jats:sub>3<\/jats:sub>\n                    OH within noncationic donor\u2013\n                    <jats:italic>\u03c0<\/jats:italic>\n                    \u2013acceptor (D\u2013\n                    <jats:italic>\u03c0<\/jats:italic>\n                    \u2013A) assemblies as amphiphilic photosensitizers (PSs) for glioblastoma photodynamic therapy (PDT). Emphasis is placed on light\u2010induced apoptosis, mitochondrial disruption in glioma\u2010derived cells, along with the already reported anti\u2010HIV properties, indicating potential for dual\u2010action therapy in immunocompromised individuals. Given the critical need for therapies effective in immunocompromised patients, further investigation into noncationic P\u2010F dyads could yield dual\u2010action agents. P\u2010F dyads were administered to tumour\u2010derived as well as nontransformed cells and subjected to PDT. PB\n                    <jats:sub>3<\/jats:sub>\n                    C\n                    <jats:sub>60<\/jats:sub>\n                    exhibited the highest selective phototoxicity in gliomblastoma cells under PDT, inducing apoptosis with moderate ROS and mitochondrial fragmentation. PB\n                    <jats:sub>3<\/jats:sub>\n                    OH caused nonspecific cytotoxicity via excessive ROS, while PB\n                    <jats:sub>3<\/jats:sub>\n                    C\n                    <jats:sub>70<\/jats:sub>\n                    triggered apoptosis even without light. PB\n                    <jats:sub>3<\/jats:sub>\n                    C\n                    <jats:sub>60<\/jats:sub>\n                    showed strong potential as a targeted photosensitizer for glioblastoma, with light\u2010dependent selectivity for cancer cells. Unlike PB\n                    <jats:sub>3<\/jats:sub>\n                    OH and PB\n                    <jats:sub>3<\/jats:sub>\n                    C\n                    <jats:sub>70<\/jats:sub>\n                    , its apoptotic effect was both specific and light activated, highlighting PB\n                    <jats:sub>3<\/jats:sub>\n                    C\n                    <jats:sub>60<\/jats:sub>\n                    's promise as a nanohybrid therapeutic for glioblastoma.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202500449","type":"journal-article","created":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T06:44:55Z","timestamp":1763880295000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Photodynamic Anticancer Efficacy of\n                    <i>meso<\/i>\n                    \u2010tris\u2010\n                    <i>p<\/i>\n                    \u2010Carboxyphenylporphyrin\u2010Fullerene Dyads: Apoptosis Induction and Mitochondrial Deregulation in Glioblastoma Therapy"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2708-8084","authenticated-orcid":false,"given":"Debdulal","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Chemistry Assam University  Silchar 788011 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5914-6838","authenticated-orcid":false,"given":"Madhumanti","family":"Halder","sequence":"additional","affiliation":[{"name":"Biophysics &amp; Structural Genomics Division Saha Institute of Nuclear Physics  Kolkata West Bengal 700064 India"},{"name":"Homi Bhabha National Institute  Mumbai Maharashtra 400094 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8044-0425","authenticated-orcid":false,"given":"Prem","family":"Das","sequence":"additional","affiliation":[{"name":"Biophysics &amp; Structural Genomics Division Saha Institute of Nuclear Physics  Kolkata West Bengal 700064 India"},{"name":"Homi Bhabha National Institute  Mumbai Maharashtra 400094 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1509-3679","authenticated-orcid":false,"given":"Oishee","family":"Chakrabarti","sequence":"additional","affiliation":[{"name":"Biophysics &amp; Structural Genomics Division Saha Institute of Nuclear Physics  Kolkata West Bengal 700064 India"},{"name":"Homi Bhabha National Institute  Mumbai Maharashtra 400094 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7512-8664","authenticated-orcid":false,"given":"Devashish","family":"Sengupta","sequence":"additional","affiliation":[{"name":"Department of Chemistry Assam University  Silchar 788011 India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.14791\/btrt.2016.4.2.77"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107308"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-019-0177-5"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/0001-3765201820170811"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12668-023-01104-2"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.37349\/etat.2025.1002303"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25147525"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/B915149B"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5NR07849K"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpx.2024.100281"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-97-8086-0_11"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b01077"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S476601"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2014.1963"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.116398"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8pp00195b"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/b711141j"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.4c00187"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano14231879"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4TB01314J"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.6060\/mhc2011.3.08"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020749"},{"key":"e_1_2_11_24_1","volume":"37","author":"Debnath A.","year":"1994","journal-title":"J. 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