{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:54:30Z","timestamp":1782993270823,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2025,9,11]]},"abstract":"<jats:p>\n                    Ferroptosis, a form of regulated cell death characterized by excessive lipid peroxidation, has been implicated in various neurological disorders. Ferrostatin\u20101 (Fer\u20101), a well\u2010known ferroptosis inhibitor, exhibits therapeutic potential but suffers from poor metabolic stability, limiting its applications. In this study, a phenotype\u2010based screening of an in\u2010house compound library is conducted and a novel ferroptosis inhibitor,\n                    <jats:bold>TJC\u20102\u20101<\/jats:bold>\n                    , is identified. To optimize its inhibitory activity, a series of 35 indoline derivatives are synthesized and evaluated. Among them, compound\n                    <jats:bold>14<\/jats:bold>\n                    exhibits the most potent inhibition against erastin\u2010induced (EC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u20090.15\u2009\u03bcM) and RSL3\u2010induced (EC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u20090.15\u2009\u03bcM) ferroptosis in HT22 mouse hippocampal cells. Mechanistic investigations reveal that compound\n                    <jats:bold>14<\/jats:bold>\n                    functions as a novel radical\u2010trapping antioxidant, exhibiting lipid peroxidation scavenging capacity comparable to that of Fer\u20101. Remarkably, compound\n                    <jats:bold>14<\/jats:bold>\n                    demonstrates significantly improved microsomal metabolic stability compared to Fer\u20101. These findings suggest that compound\n                    <jats:bold>14<\/jats:bold>\n                    has the potential to serve as a lead compound for ferroptosis\u2010related diseases.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202500487","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T17:24:38Z","timestamp":1755537878000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Novel Indoline Derivatives as Ferroptosis Inhibitors: Synthesis, Biological Evaluation, and Mechanistic Investigation"],"prefix":"10.1002","volume":"20","author":[{"given":"Wen","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases The Key Laboratory of Advanced Interdisciplinary Studies State Key Laboratory of Respiratory Disease The First Affiliated Hospital Guangzhou Medical University  Guangzhou 511436 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Respiratory Disease The First Affiliated Hospital Guangzhou Medical University  Guangzhou 511436 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xupeng","family":"Huang","sequence":"additional","affiliation":[{"name":"Innovative Center for Pathogen Research Guangzhou National Laboratory  Guangzhou 510005 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Innovative Center for Pathogen Research Guangzhou National Laboratory  Guangzhou 510005 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1252-6312","authenticated-orcid":false,"given":"Yuying","family":"Fang","sequence":"additional","affiliation":[{"name":"Innovative Center for Pathogen Research Guangzhou National Laboratory  Guangzhou 510005 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