{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:13:19Z","timestamp":1790647999113,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007428","name":"Naito Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010GM129325"],"award-info":[{"award-number":["R01\u2010GM129325"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2025,9,11]]},"abstract":"<jats:p>\n                    In this study, a passively membrane\u2010permeable short peptide inhibitor targeting the measles virus fusion protein (MeV\u2010F) is reported. Measles virus (MeV) is highly contagious, yet no approved antiviral drugs are currently available. MeV\u2010F plays a crucial role in viral infection, making it an attractive target for drug development. The fusion inhibitor peptide (FIP) is a well\u2010known short peptide that binds to MeV\u2010F and prevents its structural rearrangement. However, improving both inhibitory activity and passive membrane permeability is essential for developing orally available MeV\u2010F inhibitors. Herein, FIP derivatives are explored through hydrogen\u2010to\u2010fluorine substitution and a derivative with enhanced inhibitory activity (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u200990\u2009nM) and passive membrane permeability (\n                    <jats:italic>P<\/jats:italic>\n                    <jats:sub>e<\/jats:sub>\n                    \u2009=\u20091.4\u2009\u00d7\u200910\n                    <jats:sup>\u20136<\/jats:sup>\n                    cm\u2009s\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) was identified. This study highlights the potential of the long\u2010studied fusion inhibitor peptide as a promising lead compound for the development of orally available drugs against measles infection.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202500532","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T20:04:03Z","timestamp":1753733043000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Short Peptide Inhibitor of Measles Virus Fusion Protein that Exhibits Passive Membrane Permeability"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7233-3687","authenticated-orcid":false,"given":"Ziwei","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Chemistry &amp; Biotechnology Graduate School of Engineering The University of Tokyo  7\u20103\u20101 Hongo Bunkyo\u2010ku Tokyo 113\u20138656 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5129-2336","authenticated-orcid":false,"given":"Jiei","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Virology Institute for Life and Medical Sciences Kyoto University  Kyoto 606\u20138507 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6946-3850","authenticated-orcid":false,"given":"Tateki","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Virology Institute for Life and Medical Sciences Kyoto University  Kyoto 606\u20138507 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0275-7237","authenticated-orcid":false,"given":"Shinsuke","family":"Sando","sequence":"additional","affiliation":[{"name":"Department of Chemistry &amp; Biotechnology Graduate School of Engineering The University of Tokyo  7\u20103\u20101 Hongo Bunkyo\u2010ku Tokyo 113\u20138656 Japan"},{"name":"Department of Bioengineering Graduate School of Engineering The University of Tokyo  7\u20103\u20101 Hongo Bunkyo\u2010ku Tokyo 113\u20138656 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7578-7571","authenticated-orcid":false,"given":"Takao","family":"Hashiguchi","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Virology Institute for Life and Medical Sciences Kyoto University  Kyoto 606\u20138507 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8393-9616","authenticated-orcid":false,"given":"Jumpei","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Department of Chemistry &amp; Biotechnology Graduate School of Engineering The University of Tokyo  7\u20103\u20101 Hongo Bunkyo\u2010ku Tokyo 113\u20138656 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7063839"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S002217240006160X"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30307-9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(24)00181-6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-03043-4"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2022.04.005"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/35022579"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10639"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002240"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/v8040112"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.9.3755-3761.2005"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)38328-0"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4MD01006J"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-021-00691-y"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adm8693"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02436-13"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01554-16"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1718957115"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmch.2014.11.001"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00258"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.9.4399-4401.2001"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.4792"}],"container-title":["ChemMedChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.202500532","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cmdc.202500532","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.202500532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:47:33Z","timestamp":1773049653000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cmdc.202500532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,28]]},"references-count":22,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2025,9,11]]}},"alternative-id":["10.1002\/cmdc.202500532"],"URL":"https:\/\/doi.org\/10.1002\/cmdc.202500532","archive":["Portico"],"relation":{},"ISSN":["1860-7179","1860-7187"],"issn-type":[{"value":"1860-7179","type":"print"},{"value":"1860-7187","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,28]]},"assertion":[{"value":"2025-07-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202500532"}}