{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T12:01:44Z","timestamp":1775908904728,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000001","name":"Alberta Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005303","name":"Allard Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005303","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2025,12,15]]},"abstract":"<jats:p>\n                    The muscarinic acetylcholine receptor subtype M3 is validated as a promising target for imaging and therapy in breast cancer. Transcriptomic and proteomic profiling reveal its overexpression, particularly in triple\u2010negative breast cancer. To overcome challenges in developing selective M3 inhibitors, fluorinated peptidomimetic compounds are designed featuring a \u03b2\u2010alanine\u2010glycine scaffold that mimics key M3 pharmacophore elements. These constructs show strong potential as lead structures for\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010labeled positron emission tomography (PET) radioligands, as demonstrated with lead compound\n                    <jats:bold>24<\/jats:bold>\n                    , exhibiting M3\u2010selective binding (M1\/M3, M2\/M3, M4\/M3, and M5\/M3\u2009&gt;\u200945) with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 0.3\u2009\u03bcM. Compound\n                    <jats:bold>[<\/jats:bold>\n                    <jats:sup>\n                      <jats:bold>18<\/jats:bold>\n                    <\/jats:sup>\n                    <jats:bold>F]24<\/jats:bold>\n                    is prepared as the first M3\u2010selective PET radioligand using reductive amination with 4\u2010[\n                    <jats:sup>18<\/jats:sup>\n                    F]fluorobenzaldehyde, in a 35% decay\u2010corrected radiochemical yield. Radioligand\n                    <jats:bold>[<\/jats:bold>\n                    <jats:sup>\n                      <jats:bold>18<\/jats:bold>\n                    <\/jats:sup>\n                    <jats:bold>F]24<\/jats:bold>\n                    is tested for PET imaging of M3 receptors in preclinical breast cancer models.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202500572","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:06:00Z","timestamp":1761656760000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synthesis and Evaluation of Fluorinated Peptidomimetics Enabling the Development of\n                    <sup>18<\/sup>\n                    F\u2010Labeled Radioligands Targeting Muscarinic Acetylcholine Receptor Subtype M3"],"prefix":"10.1002","volume":"20","author":[{"given":"Miguel 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Alberta T6G 2E1 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6705-6450","authenticated-orcid":false,"given":"Frank","family":"Wuest","sequence":"additional","affiliation":[{"name":"Department of Oncology Cross Cancer Institute University of Alberta  Edmonton Alberta T6G 1Z2 Canada"},{"name":"Department of Chemistry University of Alberta  11227 Saskatchewan Drive Edmonton Alberta T6G 2G2 Canada"},{"name":"Cancer Research Institute of Northern Alberta  87 Ave. and 112 St. Edmonton Alberta T6G 2E1 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"World Cancer Report 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