{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:02:00Z","timestamp":1762732920104,"version":"build-2065373602"},"reference-count":60,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T00:00:00Z","timestamp":1757808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2025,11,6]]},"abstract":"<jats:p>\n                    In recent years, curcumin analogs have not only demonstrated potent anticancer activities but have also addressed several limitations of curcumin itself, thereby remaining a promising focus of research within the scientific community. Building upon the findings of our previous studies, structural modifications of potent curcumin analogs fused with 1\n                    <jats:italic>H<\/jats:italic>\n                    \u2010pyrazole are performed by applying the bioisosteric replacement strategy of a benzene ring with a pyridine ring, to develop a series of novel curcumin analogs containing pyrazole\u2013pyridine hybrids (\n                    <jats:bold>3a<\/jats:bold>\n                    <jats:bold>\u20134h<\/jats:bold>\n                    ) as promising anticancer agents. Among them, curcumin analog\n                    <jats:bold>4c<\/jats:bold>\n                    emerges as the most potent compound, exhibiting the strongest cytotoxicity against various human cancer cell lines, including HepG2 (liver), MDA\u2010MB\u2010231 (breast), and A549 (lung), as well as significant apoptosis\u2010inducing effects in HepG2 cells. Furthermore, compound\n                    <jats:bold>4c<\/jats:bold>\n                    is predicted to possess a favorable physicochemical\u2013pharmacokinetic\u2013toxicological profile, as well as an effective binding mode at the colchicine\u2010binding site of the\n                    <jats:italic>\u03b1<\/jats:italic>\n                    ,\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010tubulin heterodimer. Importantly, the bioisosteric replacement in compound\n                    <jats:bold>4c<\/jats:bold>\n                    is found to exert beneficial effects on its anticancer activities, physicochemical\u2013pharmacokinetic\u2013toxicological properties, and binding affinity, in comparison with its parent compounds.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202500577","type":"journal-article","created":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T13:26:57Z","timestamp":1757856417000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Curcumin Analogs Containing Pyrazole\u2013Pyridine Hybrids as Novel Anticancer Agents: Synthesis, Cytotoxicity, Apoptosis Induction, and Molecular Modeling"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4048-1884","authenticated-orcid":false,"given":"Nam Q. 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