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However, conventional gas\u2010releasing molecules (GRMs) suffer from core problems such as uncontrollable release, poor targeting, and insufficient stability. To address these challenges, nanoplatforms represented by metal\u2010organic frameworks (MOFs) offer an innovative solution. MOFs, with their high specific surface area, tunable porosity, and abundant active sites, are able to significantly enhance the storage and release efficiency of gases. In particular, the high specific surface area and porosity of MOFs enable efficient loading of therapeutic gases and targeted release of gases through precise regulation of porosity; their abundant active sites enhance the stability and controllability of gas release. This review focuses on the preparation and modulation of MOF, systematically describes the advantages of MOF\u2010based GRM nanoplatforms in the efficient loading and responsive release of therapeutic gases, such as oxygen (O\n                    <jats:sub>2<\/jats:sub>\n                    ), nitric oxide (NO), and hydrogen (H\n                    <jats:sub>2<\/jats:sub>\n                    ), and summarizes their recent progress in the field of GT for tumor treatment. Finally, the challenges and future perspectives of GT\u2010 and MOF\u2010based GRM nanoplatforms are discussed to provide more effective and safer therapeutic strategies for clinical applications.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202500602","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T15:40:25Z","timestamp":1756395625000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Multifunctional Responsive Gas\u2010Releasing Metal Organic Framework Nanoplatform for Tumor Therapy Application"],"prefix":"10.1002","volume":"20","author":[{"given":"Yue","family":"Meng","sequence":"first","affiliation":[{"name":"College of Chemistry Chemical Engineering and Resource Utilization, Northeast Forestry University  Harbin 150040 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Chemistry Chemical Engineering and Resource Utilization, Northeast Forestry University  Harbin 150040 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangwei","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Chemistry Chemical Engineering and Resource Utilization, Northeast Forestry University  Harbin 150040 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8739-3905","authenticated-orcid":false,"given":"Ruixuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Jiao Tong University School of Medicine Ruijin Hospital Shanghai Institute of Traumatology and Orthopedics  Shanghai 200025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1039-3926","authenticated-orcid":false,"given":"Ding","family":"Dai","sequence":"additional","affiliation":[{"name":"College of Chemistry Chemical Engineering and Resource Utilization, Northeast Forestry University  Harbin 150040 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5799-585X","authenticated-orcid":false,"given":"Yuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Centre of Pharmaceutical Engineering and Technology Harbin University of Commerce  Harbin 150028 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7004-9235","authenticated-orcid":false,"given":"Tiedong","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Chemistry Chemical Engineering and Resource Utilization, Northeast Forestry University  Harbin 150040 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b04954"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.143969"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3228"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2425"},{"key":"e_1_2_6_6_1","first-page":"147","volume":"1","author":"Huerta S.","year":"1992","journal-title":"Int. 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