{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:19:02Z","timestamp":1791256742309,"version":"4.1.0"},"reference-count":75,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2025,11,28]]},"abstract":"<jats:p>\n                    A series of 2\u2010iminothiazolidin\u20104\u2010one\u20131,3,4\u2010thiazole hybrids\n                    <jats:bold>7a\u2013l<\/jats:bold>\n                    are synthesized and screened for their inhibitory activities against responsible enzymes in type 2 diabetes mellitus (T2DM) and Alzheimer's diseases. Among the compounds with potential inhibitory activity, several 2\u2010iminothiazolidin\u20104\u2010ones exhibit the strongest inhibitory activity against the screened enzymes, including\n                    <jats:bold>7c<\/jats:bold>\n                    (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 6.12\u2009\u00b1\u20090.11\u2009\u00b5M, for \u03b1\u2010amylase),\n                    <jats:bold>7e<\/jats:bold>\n                    (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 6.78\u2009\u00b1\u20090.15\u2009\u00b5M, for \u03b1\u2010glucosidase),\n                    <jats:bold>7k<\/jats:bold>\n                    (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 1.82\u2009\u00b1\u20090.04\u2009\u00b5M, for DPP\u20104),\n                    <jats:bold>7f<\/jats:bold>\n                    (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 2.21\u2009\u00b1\u20090.02\u2009\u00b5M, for PTP1B),\n                    <jats:bold>7h<\/jats:bold>\n                    (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 0.06\u2009\u00b1\u20090.01\u2009nM, for AChE),\n                    <jats:bold>7j<\/jats:bold>\n                    (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 0.03\u2009\u00b1\u20090.01\u2009nM, for BChE, and IC\n                    <jats:sub>50<\/jats:sub>\n                    = 0.32\u2009\u00b1\u20090.01\u2009nM, for MAO\u2010A), and\n                    <jats:bold>7l<\/jats:bold>\n                    (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 0.02\u2009\u00b1\u20090.01\u2009nM, for MAO\u2010B). Compound\n                    <jats:bold>7j<\/jats:bold>\n                    exhibits the strongest inhibitory activity for both BChE and MAO\u2010A. Compounds with short\u2010chain alkyl groups (2\u20134 carbon atoms) have the strongest inhibitory activity against the enzymes responsible in T2DM, with the exception of\n                    <jats:bold>7k<\/jats:bold>\n                    (with 6\u2010carbon atom chain), whereas the long\u2010chain alkyl groups (with 5\u20137 carbon atom chains) have the strongest inhibitory activity against the enzymes responsible in Alzheimer's disease. These compounds also exhibit the high antiglycation and antioxidant activity in DPPH and ABTS\n                    <jats:sup>\u2022+<\/jats:sup>\n                    scavenging assays. They are noncytotoxic for WI\u201038 cell line with IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009&gt;\u200976\u2009\u03bcM.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202500620","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T22:45:17Z","timestamp":1760654717000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synthesis and Biological Activity for 1,3,4\u2010Thiadiazole\u20132\u2010Iminothiazolidin\u20104\u2010Ones: Antidiabetic and Anti\u2010Alzheimer Activity"],"prefix":"10.1002","volume":"20","author":[{"given":"Vu Ngoc","family":"Toan","sequence":"first","affiliation":[{"name":"Institute of Materials, Biology and Environment Military Institute of Science and Technology  17 Hoang Sam Nghia Do 11300 Ha Noi Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2267-1775","authenticated-orcid":false,"given":"Nguyen Dinh","family":"Thanh","sequence":"additional","affiliation":[{"name":"Department of Chemistry VNU University of Science  19 Le Thanh Tong Cua Nam 11000 Ha Noi Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Minh","family":"Tri","sequence":"additional","affiliation":[{"name":"Institute of Materials, Biology and Environment Military Institute of Science and Technology  17 Hoang Sam Nghia Do 11300 Ha Noi Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9061713"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-023-01628-z"},{"key":"e_1_2_6_4_1","first-page":"S20","volume":"47","author":"Committee A. 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