{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:54:13Z","timestamp":1792205653388,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2025,11,18]]},"abstract":"<jats:p>\n                    Photo\u2010labile protecting groups (PPG) allow for the selective activation of an originally caged moiety by light exposure at a specific wavelength. Incorporation of PPG in nanoparticles (NPs) enables precise spatiotemporal control over NPs surface properties. Thus, physicochemical and biological properties of NPs can be modified even after administration in a biological environment. In this study, this mechanism is used to control the cell uptake of NPs. To this end, polymeric core\u2013shell NPs are used composed of poly(D, L\u2010lactide\u2010co\u2010glycolide) and a poly(ethylene glycol)\u2010b\u2010poly(D, L\u2010lactide) block copolymer, modified with positively charged cell\u2010penetrating peptide (CPP). Surface charge of CPP\u2010NPs (+23.50\u2009mV), measured as zetapotential, is effectively diminished by the attachment of coumarin\u2010derived PPG to CPP (+12.50\u2009mV), resulting in reduced cell uptake. Upon light irradiation with light\u2010emitting diode (\n                    <jats:italic>\u03bb\u2009<\/jats:italic>\n                    =\u2009365\u2009nm) the PPG is cleaved, restoring the zetapotential (+24.67\u2009mV) and triggering an enhanced cell uptake. This opens the door to trigger the cellular uptake of NPs that are intended to transport drugs to their target cells in the future.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202500636","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:32:04Z","timestamp":1759883524000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Coumarin\u2010Caged Nanoparticle for Light\u2010Driven Surface Modification"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1847-2075","authenticated-orcid":false,"given":"Jan","family":"Birringer","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Technology University of Regensburg  Regensburg 93053 Bavaria 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