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The yttrium derivative is structurally characterized by single\u2010crystal X\u2010ray diffraction, IR, and NMR spectroscopy, showing the mononuclear nature of the complex, while the structure of the other paramagnetic complexes are assigned on comparative IR spectra bases and elemental analyses. The antiproliferative effect of the complexes are studied in\u2009vitro on a panel of human tumor cell lines (A2780, ovarian carcinoma sensitive to cisplatin; A2780cis, ovarian carcinoma resistant to cisplatin and LN229, glioblastoma), and on nontumorigenic mesothelial cells (MeT\u20105A). The reactive oxygen species production is determined to investigate the intracellular mechanism of action. For the most interesting complex [Dy(sal)\n                    <jats:sub>3<\/jats:sub>\n                    (phen)] (\n                    <jats:bold>3<\/jats:bold>\n                    ), the effects on mitochondrial transmembrane potential and on cell cycle are also analyzed. Finally, epifluorescence images allow to demonstrate the uptake of the complex and to observe relevant morphological changes in cells, suggesting the occurrence of mitotic catastrophe.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202500654","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T15:23:34Z","timestamp":1764084214000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rare\u2010Earth Salicylate Phenanthroline Complexes Cause Cell Death in Human Tumor Cells"],"prefix":"10.1002","volume":"21","author":[{"given":"Elena","family":"Catania","sequence":"first","affiliation":[{"name":"Dipartimento di Chimica e Chimica Industriale Universit\u00e0 di Pisa  Via Giuseppe Moruzzi 13 56124 Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Bazi","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica e Chimica Industriale Universit\u00e0 di Pisa  Via Giuseppe Moruzzi 13 56124 Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Bellucci","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica e Chimica Industriale Universit\u00e0 di Pisa  Via Giuseppe Moruzzi 13 56124 Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Guelfi","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica e Chimica Industriale Universit\u00e0 di Pisa  Via Giuseppe Moruzzi 13 56124 Pisa Italy"},{"name":"Centro per l\u2019Integrazione della Strumentazione Scientifica dell\u2019Universit\u00e0 di Pisa (C.I.S.U.P.) 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