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Furthermore, as all the title compounds are fluorine\u2010containing molecules, it seemed to be reasonable to explore the role of fluorine atoms in the aromatic system and to determine the optimal position at the terminal phenoxy group, and therefore, various regioisomers are prepared. The conformationally restricted selenocyates structurally related to WC\u20109Se exhibited improved antiparasitic activity compared to the lead drugs, Out to be extremely potent inhibitors of\n                    <jats:italic>T. cruzi<\/jats:italic>\n                    growth. In particular, (\u00b1)\u20105\u2010(3\u2010fluorophenoxy)\u20102\u2010(selenocyanatomethyl)\u22122,3\u2010dihydrobenzofuran exhibited an EC\n                    <jats:sub>50<\/jats:sub>\n                    value of 0.032 \u00b5M, which resulted in the most potent selenocyanate developed in the laboratory. The presence of the fluorine atom together with the rigidity of the molecules are beneficial for the anti\u2010\n                    <jats:italic>T. cruzi<\/jats:italic>\n                    effect. The resulting antiparasitic activity provides further insight into the role of the selenocyanate group in its effective and putative anti\u2010\n                    <jats:italic>T. cruzi<\/jats:italic>\n                    action.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202500658","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T18:16:17Z","timestamp":1762884977000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Selenocyanate\u2010Containing Molecules as\n                    <i>Trypanosoma cruzi<\/i>\n                    Inhibitors: Impact of Regioisomerism, Conformational Restriction, and Second\u2010Ring Substitution"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6513-4910","authenticated-orcid":false,"given":"Hugo S.","family":"Steingr\u00fcber","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires Ciudad Universitaria  Intendente G\u00fciraldes 2160 Buenos Aires Argentina"},{"name":"Unidad de Microan\u00e1lisis y M\u00e9todos F\u00edsicos aplicados a Qu\u00edmica Org\u00e1nica (UMYMFOR) CONICET  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2489-434X","authenticated-orcid":false,"given":"Mayara S.","family":"Bertolini","sequence":"additional","affiliation":[{"name":"Center for Tropical and Emerging Global Diseases and Department of Cellular Biology University of Georgia  Athens GA 30602 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4811-1194","authenticated-orcid":false,"given":"Margarita M.","family":"Vallejos","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica IQUIBA\u2010NEA CONICET, FACENA Universidad Nacional del Nordeste  Av. Libertad 5460 Corrientes 3400 Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6989-4768","authenticated-orcid":false,"given":"Sergio H.","family":"Szajnman","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires Ciudad Universitaria  Intendente G\u00fciraldes 2160 Buenos Aires Argentina"},{"name":"Unidad de Microan\u00e1lisis y M\u00e9todos F\u00edsicos aplicados a Qu\u00edmica Org\u00e1nica (UMYMFOR) CONICET  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4229-8784","authenticated-orcid":false,"given":"Roberto","family":"Docampo","sequence":"additional","affiliation":[{"name":"Center for Tropical and Emerging Global Diseases and Department of Cellular Biology University of Georgia  Athens GA 30602 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5180-096X","authenticated-orcid":false,"given":"Juan B.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires Ciudad Universitaria  Intendente G\u00fciraldes 2160 Buenos Aires Argentina"},{"name":"Unidad de Microan\u00e1lisis y M\u00e9todos F\u00edsicos aplicados a Qu\u00edmica Org\u00e1nica (UMYMFOR) CONICET  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2016.1209487"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2009.11.003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2019.00166"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-9292-3-2"},{"key":"e_1_2_9_6_1","first-page":"33","volume":"90","year":"2015","journal-title":"Wkly. 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