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Herein, an iron\/\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010cyclodextrin (Fe(II)\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010CD) nanocomplex, synthesized at room temperature is characterized by various analytical techniques. The complex has a morphology of irregular\u2010particles with an average of 4\u201310\u2009nm, and displays a porous structure. In\u2009vitro, the particles are well\u2010dispersible in the culture medium, which is typically an aqueous solution at pH\u2009=\u20097.4. The particles are stable under physiological conditions and biocompatible with living cells, making them a promising drug\u2010delivery platform candidate. The Fe(II)\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010CD is screened for its anticancer potential against four types of malignant cell lines: liver(HepG2), breast(A549), lung(MCF7), and prostate(PC3) for the evaluation of prospective cytotoxicity properties. The results reveal that the nanocomplex show no cytotoxic effect. The dose response curves and the IC\n                    <jats:sub>50<\/jats:sub>\n                    of the sample on each cell line are evaluated at different incubation time intervals. The apoptotic mode of cell death is the prevailing mode after 24 and 48\u2009h. Moreover, the molecular docking for the nanocomplex as an anticancer drug against the active site of CD44 glycoprotein (PDB\u2010ID\u20101poz) is investigated. Based on the obtained results, the prepared complex paves the way for similar biomarkers in cancer treatment.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202500665","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T20:22:07Z","timestamp":1761769327000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Apoptosis\u2010Inducing Fe\n                    <sup>2+<\/sup>\n                    \/\n                    <i>\u03b2<\/i>\n                    \u2010Cyclodextrin Supramolecular Nano\u2013Particulate Complex as an Anticancer Drug Platform and Cancer\u2010Diagnostic Tool Prototype"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8069-7105","authenticated-orcid":false,"given":"Sheta M.","family":"Sheta","sequence":"first","affiliation":[{"name":"Inorganic Chemistry Department National Research Centre  33 El\u2010Behouth Street Dokki 12622 Giza Egypt"},{"name":"Institute of Inorganic and Structural Chemistry Heinrich\u2010Heine\u2010Universit\u00e4t D\u00fcsseldorf  Universit\u00e4tsstr. 1 40225 D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Said M.","family":"El\u2010Sheikh","sequence":"additional","affiliation":[{"name":"Nanomaterials and Nanotechnology Department Central Metallurgical R &amp; D Institute  Cairo 11421 Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud T.","family":"Abo\u2010Elfadl","sequence":"additional","affiliation":[{"name":"Cancer Biology and Genetics Laboratory Centre of Excellence for Advanced Sciences National Research Centre  Dokki 12622 Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Younis","sequence":"additional","affiliation":[{"name":"Green Chemistry Department National Research Centre Chemical Industries Institute  33 El\u2010Behouth Street. 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