{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:38:11Z","timestamp":1786977491610,"version":"build-2736575974"},"reference-count":12,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["BE 4572\/6\u20101"],"award-info":[{"award-number":["BE 4572\/6\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2025,11,6]]},"abstract":"<jats:p>\n                    The transcription factor signal transducer and activator of transcription (STAT)4 is a potential target for autoimmune diseases, such as inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and diabetes mellitus.\n                    <jats:italic>p<\/jats:italic>\n                    \u2010Biphenyl phosphate is reported as an inhibitor of the STAT4 Src homology 2 domain, and it is developed to the phosphonate\u2010based inhibitor Stafori\u20101. Herein, structure\u2013activity relationships of\n                    <jats:italic>p<\/jats:italic>\n                    \u2010biaryl phosphates against STAT4 and their selectivity profiles against other STAT proteins are reported. The most potent biaryl phosphate\u2010based inhibitor originating from this article, Stafori\u20102, contains the same aryl moieties as the phosphonate Stafori\u20101. However, Stafori\u20102 is more potent than Stafori\u20101 in fluorescence polarization assays and by isothermal titration calorimetry.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202500672","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T16:15:39Z","timestamp":1757434539000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Biaryl Phosphate\u2010Based Inhibitors of the Transcription Factor STAT4"],"prefix":"10.1002","volume":"20","author":[{"given":"Nadiya","family":"Brovchenko","sequence":"first","affiliation":[{"name":"Institute of Organic Chemistry Leipzig University  Johannisallee 29 04103 Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Maria","family":"Oelsch","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry Leipzig University  Johannisallee 29 04103 Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7910-6371","authenticated-orcid":false,"given":"Christoph","family":"Protzel","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry Leipzig University  Johannisallee 29 04103 Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3109-7696","authenticated-orcid":false,"given":"Thorsten","family":"Berg","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry Leipzig University  Johannisallee 29 04103 Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm909"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2014.920325"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.5.1844"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.21.120601.140942"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202504420"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202500454"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/mps5060093"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0282(2001)60:1<32::AID-BIP1002>3.0.CO;2-I"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c00220"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b01530"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac3007522"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2004.05.055"}],"container-title":["ChemMedChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.202500672","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T23:57:25Z","timestamp":1762732645000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cmdc.202500672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,9]]},"references-count":12,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2025,11,6]]}},"alternative-id":["10.1002\/cmdc.202500672"],"URL":"https:\/\/doi.org\/10.1002\/cmdc.202500672","archive":["Portico"],"relation":{},"ISSN":["1860-7179","1860-7187"],"issn-type":[{"value":"1860-7179","type":"print"},{"value":"1860-7187","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,9]]},"assertion":[{"value":"2025-08-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202500672"}}