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This sPA serve a dual role as both reducing and stabilizing agent for silver nanoparticles (AgNPs). Designed with self\u2010assembling capabilities, the sPA spontaneously form polydispersed heterogeneous supramolecular nanostructures and simultaneously enable the in\u2009situ photoreduction of Ag(I) ions under mild sunlight exposure, owing to the intrinsic photophysical and redox\u2010active properties of tryptophan residues. The resulting AgNP\u2010sPA hybrids display well\u2010defined polydispersed morphologies, confirmed through detailed spectroscopic and microscopic analyses. These nanoconjugates show excellent colloidal stability and strong interactions with bacterial membranes. Antibacterial assessments reveal that the AgNP\u2010sPA hybrids exhibit potent and broad\u2010spectrum activity against both Gram\u2010positive (e.g.,\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ) and Gram\u2010negative pathogens, including\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    (standard and clinical strains),\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    ,\n                    <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                    , and\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    . Notably, the hybrids demonstrate superior efficacy compared to the conventional antibiotic levofloxacin. Importantly, the AgNP\u2010sPA nanostructures also exhibit significant inhibitory activity against multidrug\u2010resistant strains such as methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA) and vancomycin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (VRSA), highlighting their potential in tackling antibiotic\u2010resistant infections.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202500679","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T02:00:14Z","timestamp":1761703214000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tryptophan\u2010Rich Short Peptide Amphiphile\u2010Mediated Synthesis of Silver Nanoparticles for Potent Antibacterial 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