{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T08:11:21Z","timestamp":1778141481205,"version":"3.51.4"},"reference-count":65,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,3,13]]},"abstract":"<jats:p>\n                    This article seeks to develop new antioxidant agents to address the rising prevalence of oxidative stress\u2010associated disorders. This research outlines a high\u2010yielding synthetic approach to functionalized pyrazolo[5,1\u2010b]quinazoline tethered 1,2,3\u2010triazole derivatives\n                    <jats:bold>7(a\u2010x)<\/jats:bold>\n                    using L\u2010proline as a catalyst under microwave irradiation. The synthesized compounds were evaluated for their in vitro antioxidant activity using 2,2\u2032\u2010azino\u2010bis(3\u2010ethylbenzothiazoline\u20106\u2010sulfonic acid) (ABTS) and 2,2\u2010diphenyl\u20101\u2010picrylhydrazyl (DPPH) radical as well as hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) scavenging assays. In all assays, compounds\n                    <jats:bold>7a, 7b, 7c, 7d, 7m, 7n, 7o,<\/jats:bold>\n                    and\n                    <jats:bold>7p<\/jats:bold>\n                    exhibited significantly greater antioxidant activity compared to the reference standard, ascorbic acid. Molecular docking study reinforced the experimental findings, showing that the compounds engage in multiple binding interactions within the active sites of both enzymes. Additionally, density functional theory (DFT) analysis was also performed to examine the electronic and molecular properties of the compounds, revealing strong agreement between theoretical predictions and experimental results. Overall, the results highlight these derivatives as promising lead candidates for antioxidant drug development, supported by robust evidence from molecular docking and DFT analyses.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202500683","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:01:11Z","timestamp":1773360071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Discovery of Pyrazolo[5,1\u2010b]quinazoline Tethered 1,2,3\u2010Triazole Analogs as Potential Antioxidant Agents: Design, Synthesis, Biological Evaluation, and In Silico Insights"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1182-1025","authenticated-orcid":false,"given":"Reena C.","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Chemistry Sardar Patel University  Vallabh Vidyanagar India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaushal B.","family":"Parmar","sequence":"additional","affiliation":[{"name":"Department of Chemistry Sardar Patel University  Vallabh Vidyanagar India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6650-2244","authenticated-orcid":false,"given":"Manish P.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Chemistry Sardar Patel University  Vallabh Vidyanagar India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0254-6272(15)30067-4"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfca.2014.01.003"},{"key":"e_1_2_10_4_1","first-page":"1773","article-title":"Antioxidant Deficiency in Sera of Patients with Diabetes Mellitus Infected with COVID\u201019","volume":"49","author":"Yang H.","year":"2011","journal-title":"Oxidation Communications"},{"key":"e_1_2_10_5_1","first-page":"119","article-title":"In Silico Investigation of Piperine against Human Monoamine Oxidase\u2010A (MAO\u2010A) Enzyme","volume":"2","author":"Acad S.","year":"2014","journal-title":"Scholars Academic Journal of Biosciences"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2010.06.001"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2007.02.002"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)01368-B"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a072970"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathophys.2006.05.002"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2015.03.013"},{"key":"e_1_2_10_12_1","volume-title":"Free Radical Medicine and Biology","author":"Moussa Z.","year":"2019"},{"key":"e_1_2_10_13_1","volume-title":"The Transcription Factor Nrf2","author":"Mendoza\u2010P\u00e9rez J. 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