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However, development of efficient aPDT agents that can simultaneously eradicate resistant pathogens within biofilms and host cells with good biocompatibility remains a big challenge. Herein, three novel D\u2013D\u2010\n                    <jats:italic>\u03c0<\/jats:italic>\n                    \u2010A\u2013A type dyes (TPATA, TPATC, and TPATPy) were designed and synthesized. TPATPy can efficiently produce reactive oxygen species (ROS) mainly through type I mechanism, which is beneficial for overcoming hypoxia within biofilms. Besides, introduction of pyridinium cations in TPATPy enhances the binding ability with negatively charged bacteria and biofilms through electrostatic interactions. Therefore, TPATPy not only exhibited excellent aPDT activity toward planktonic bacteria, but also destroyed mature biofilms and the embedded pathogens. Moreover, TPATPy could selectively and efficiently photo\u2010inactivate intracellular methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA), being more potent than vancomycin. So far as we know, TPATPy should be the first example that can simultaneously eradicate intractable pathogens within biofilms and host cells. The efficacy and safety of TPATPy in accelerating wound healing have also been demonstrated in an MRSA\u2010infected skin wound model in mice. These results may provide new ideas for developing multifunctional aPDT agents to solve the intractable problems in antibacterial treatment.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202500703","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T18:49:32Z","timestamp":1770922172000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Donor\u2013Donor\u2010\u03c0\u2010Acceptor\u2013Acceptor Type Photosensitizer for Efficient Photo\u2010Inactivation of Pathogens Within Biofilms and Host Cells"],"prefix":"10.1002","volume":"21","author":[{"given":"Yunli","family":"Xu","sequence":"first","affiliation":[{"name":"Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences  Beijing China"},{"name":"University of Chinese Academy of Sciences  Beijing 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