{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:38:11Z","timestamp":1786977491952,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2025GXNSFDA069055"],"award-info":[{"award-number":["2025GXNSFDA069055"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["D25019"],"award-info":[{"award-number":["D25019"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2025,11,28]]},"abstract":"<jats:p>\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    exhibits a relatively high infection rate and marked drug resistance; in severe cases, it can even progress to gastric cancer, posing a substantial threat to human health. To address this pressing issue, the synthesis of a series of 1,4\u2010naphthoquinone\u2010benzenesulfonamide derivatives and investigations into their anti\u2010\n                    <jats:italic>H. pylori<\/jats:italic>\n                    activity is reported.The synthesized compounds are characterized by\n                    <jats:sup>1<\/jats:sup>\n                    H\/\n                    <jats:sup>13<\/jats:sup>\n                    C NMR and HRESIMS. Activity evaluation assays reveal that all synthesized compounds exert notable inhibitory effects against\n                    <jats:italic>H. pylori<\/jats:italic>\n                    , with minimum inhibitory concentrations ranging from 4 to 16\u2009\u03bcg\u2009mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    (positive control: metronidazole, 4\u2009\u03bcg\u2009mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ). Compound\n                    <jats:bold>6i<\/jats:bold>\n                    induces excessive reactive oxygen species (ROS) production in\n                    <jats:italic>H. pylori<\/jats:italic>\n                    , impairs mitochondrial structure and function, reduces ATP synthesis, and ultimately leads to bacterial death. The reduction of FADH\n                    <jats:sub>2<\/jats:sub>\n                    (a key donor for the electron transport chain), electron leakage, and the decreased NADP\n                    <jats:sup>+<\/jats:sup>\n                    \/NADPH ratio further indicates that compound\n                    <jats:bold>6i<\/jats:bold>\n                    can disrupt the intracellular redox balance in bacteria. Additionally, reverse transcription quantitative polymerase chain reaction experiments confirm that compound\n                    <jats:bold>6i<\/jats:bold>\n                    downregulates the expression levels of ROS\u2010 and ATP\u2010related genes. Furthermore, molecular docking and molecular dynamics simulation experiments verify that compound\n                    <jats:bold>6i<\/jats:bold>\n                    can stably bind to the\n                    <jats:italic>M<\/jats:italic>\n                    <jats:italic>daB<\/jats:italic>\n                    gene in\n                    <jats:italic>H. pylori<\/jats:italic>\n                    , thereby exerting a downregulatory effect on\n                    <jats:italic>M<\/jats:italic>\n                    <jats:italic>daB<\/jats:italic>\n                    . Therefore, the synthesized compound\n                    <jats:bold>6i<\/jats:bold>\n                    has been confirmed to be a compound capable of disrupting the redox balance and energy metabolism of\n                    <jats:italic>H . pylori<\/jats:italic>\n                    , and this compound may serve as a lead compound against\n                    <jats:italic>H . pylori<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202500725","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T02:00:34Z","timestamp":1761703234000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synthesis of 1,4\u2010Naphthoquinone\u2010Benzenesulfonamide Derivatives with Anti\u2010\n                    <i>H. Pylori<\/i>\n                    Activity and Studies on their Mechanism of Action"],"prefix":"10.1002","volume":"20","author":[{"given":"Gang","family":"Wei","sequence":"first","affiliation":[{"name":"College of Intelligent Metallurgy Guangxi Modern Polytechnic College  Hechi Guangxi Zhuang 547000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingli","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangxi Zhuang Autonomous Region Engineering Research Center of Clinical Prevention and Control Technology and Leading Drug for Microorganisms with Drug Resistance in Border Ethnic Areasn Youjiang Medical University for Nationalities  Baise Guangxi 533000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Luo","sequence":"additional","affiliation":[{"name":"Guangxi Zhuang Autonomous Region Engineering Research Center of Clinical Prevention and Control Technology and Leading Drug for Microorganisms with Drug Resistance in Border Ethnic Areasn Youjiang Medical University for Nationalities  Baise Guangxi 533000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wei","sequence":"additional","affiliation":[{"name":"College of Intelligent Metallurgy Guangxi Modern Polytechnic College  Hechi Guangxi Zhuang 547000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuban","family":"Lei","sequence":"additional","affiliation":[{"name":"College of Intelligent Metallurgy Guangxi Modern Polytechnic College  Hechi Guangxi Zhuang 547000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhen","family":"Ma","sequence":"additional","affiliation":[{"name":"Guangxi Zhuang Autonomous Region Engineering Research Center of Clinical Prevention and Control Technology and Leading Drug for Microorganisms with Drug Resistance in Border Ethnic Areasn Youjiang Medical University for Nationalities  Baise Guangxi 533000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5731-2159","authenticated-orcid":false,"given":"Jiazi","family":"Luo","sequence":"additional","affiliation":[{"name":"Guangxi Zhuang Autonomous Region Engineering Research Center of Clinical Prevention and Control Technology and Leading Drug for Microorganisms with Drug Resistance in Border Ethnic Areasn Youjiang Medical University for Nationalities  Baise Guangxi 533000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meishan","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China) Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical Sciences Guangxi Normal University  Guilin Guangxi 541000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengshan","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China) Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical Sciences Guangxi Normal University  Guilin Guangxi 541000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.12.022"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-024-01654-2"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.1949"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(23)00070-5"},{"key":"e_1_2_9_6_1","first-page":"629","volume":"399","author":"Ranjbar R.","year":"2023","journal-title":"Evidence\u2010Based Nurs."},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202206957"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10081293"},{"key":"e_1_2_9_9_1","first-page":"644","volume":"88","author":"Catal\u0101 E. 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