{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:29:26Z","timestamp":1788920966986,"version":"build-2803163510"},"reference-count":74,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,2,25]]},"abstract":"<jats:p>\n                    Bioactive compositions containing vanadium complexes have been a viable strategy for constructing more biocompatible and less toxic systems. Therefore, this work aim to develop a new composition formed by an oxidovanadium(IV) complex as levan. The acute oral toxicity and insulin resistance (IR) are investigated in an animal model using adult Swiss mice treated with daily injections of the synthetic glucocorticoid dexamethasone. The complex is characterized by electronic absorption (\u03bb\n                    <jats:sub>max<\/jats:sub>\n                    \u2009=\u2009771 and 880\u2009nm) and infrared spectroscopies (3359, 3167, 1606, 1342, 1072\u2009cm\n                    <jats:sup>\u22121<\/jats:sup>\n                    , and the V\uf8feO at 937\u2009cm\n                    <jats:sup>\u22121<\/jats:sup>\n                    ); NMR of the\n                    <jats:sup>1<\/jats:sup>\n                    H,\n                    <jats:sup>13<\/jats:sup>\n                    C, and\n                    <jats:sup>51<\/jats:sup>\n                    V (\u2212427, \u2212509, and \u2212529\u2009ppm), and electron paramagnetic resonance (g\u2010factor\u2009=\u20091.985). The vanadium complex is classified in category 4, according to the acute toxicity protocol. IR in mice is accompanied by a rise in fasting blood glucose at seventh (2.2\u2010fold) and 14th (threefold) days, triglyceride levels at seventh (2.6\u2010fold) and 14th (threefold) days, and triglyceride\/glucose index (TyG) at seventh (20%) and 14th (25%) days. The bioactive composition attenuated both the hyperglycemia (\u224865%) and hypertriglyceridemia and TyG in a dose\u2010dependent manner. The proposed composition shows promise in reducing IR induced by exogenous corticosteroid treatment.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202500754","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T02:30:27Z","timestamp":1766025027000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the Therapeutic Potential of Bioactive Materials Based on a Complex of Oxidovanadium(IV) and Exopolysaccharide Levan in a Model of Insulin Resistance in Mice"],"prefix":"10.1002","volume":"21","author":[{"given":"Amanda K. J. P. F.","family":"da Silva","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica Universidade Federal Rural de Pernambuco  Rua Dom Manoel de Medeiros, S\/N\u2014Dois Irm\u00e3os Recife\u2010PE CEP: 52171\u2013900 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eucilene K. de L. B.","family":"Marques","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia e Farmacologia Centro de Bioci\u00eancias Universidade Federal de Pernambuco  Avenida Professor Moraes Rego, S\/N\u2014Cidade Universit\u00e1ria Recife\u2010PE CEP: 50670\u2013901 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidiane M. A.","family":"de Lima","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Universidade Federal Rural de Pernambuco  Rua Dom Manoel de Medeiros, S\/N\u2014Dois Irm\u00e3os Recife\u2010PE CEP: 52171\u2013900 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Widarlane A. S.","family":"Alves","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia e Farmacologia Centro de Bioci\u00eancias Universidade Federal de Pernambuco  Avenida Professor Moraes Rego, S\/N\u2014Cidade Universit\u00e1ria Recife\u2010PE CEP: 50670\u2013901 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayane A.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia e Farmacologia Centro de Bioci\u00eancias Universidade Federal de Pernambuco  Avenida Professor Moraes Rego, S\/N\u2014Cidade Universit\u00e1ria Recife\u2010PE CEP: 50670\u2013901 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro L.","family":"Guzzo","sequence":"additional","affiliation":[{"name":"Departamento de Engenharia de Minas Centro de Tecnologia Universidade Federal de Pernambuco  Rua Acad\u00eamico H\u00e9lio Ramos, S\/N\u2014Cidade Universit\u00e1ria Recife\u2010PE CEP: 50740\u2013530 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6545-0246","authenticated-orcid":false,"given":"M\u00f4nica F.","family":"Belian","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Universidade Federal Rural de Pernambuco  Rua Dom Manoel de Medeiros, S\/N\u2014Dois Irm\u00e3os Recife\u2010PE CEP: 52171\u2013900 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0719-5416","authenticated-orcid":false,"given":"Wagner E.","family":"Silva","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Universidade Federal Rural de Pernambuco  Rua Dom Manoel de Medeiros, S\/N\u2014Dois Irm\u00e3os Recife\u2010PE CEP: 52171\u2013900 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo C.","family":"Lira","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia e Farmacologia Centro de Bioci\u00eancias Universidade Federal de Pernambuco  Avenida Professor Moraes Rego, S\/N\u2014Cidade Universit\u00e1ria Recife\u2010PE CEP: 50670\u2013901 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01073-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2021.0280"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S330253"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.5001\/omj.2012.68"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241310927"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2019.09.011"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-0995-y"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnad016"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.33448\/rsd-v13i1.44900"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.86"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/inorganics10120244"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/525093"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph17040486"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-018-1540-6"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2020.111094"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242115675"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-009-9241-4"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2020.111312"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2023.112127"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph17060760"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1450799"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2015.03.016"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/206316"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-0134(99)00152-X"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.29252\/ibj.24.1.54"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2011.07.007"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2011.08.011"},{"key":"e_1_2_8_29_1","first-page":"801","volume":"13","author":"Kang S. 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