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Benzimidazole, a privileged heterocyclic scaffold, has emerged as a promising pharmacophore in modulating key pathological targets across these disorders. In AD, benzimidazole derivatives inhibit cholinesterases, glycogen synthase kinase\u20103\u03b2 (GSK\u20103\u03b2), and glutaminyl cyclase (QC), thereby addressing cholinergic dysfunction, tau phosphorylation, and amyloid aggregation. In PD and HD, they act as monoamine oxidase\u2010B (MAO\u2010B) inhibitors, dopamine D1\/D2 receptor modulators, and N\u2010methyl D\u2010aspartate receptor antagonists, improving dopaminergic signalling and reducing excitotoxicity. In ALS, benzimidazoles regulate acetylcholine dysfunction and inhibit receptor\u2010interacting protein kinase 1 (RIPK1), limiting neuroinflammation and cell death. 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