{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:24:30Z","timestamp":1792002270953,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004742","name":"National Academy of Sciences of Ukraine","doi-asserted-by":"publisher","award":["Novel synthetic nitrogen\u2010containing heterocyclic compounds with antimicrobial and anti\u2010cancer activity (Contract \u211629\/02\u20102024(5) from 19.02.2024"],"award-info":[{"award-number":["Novel synthetic nitrogen\u2010containing heterocyclic compounds with antimicrobial and anti\u2010cancer activity (Contract \u211629\/02\u20102024(5) from 19.02.2024"]}],"id":[{"id":"10.13039\/501100004742","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,2,25]]},"abstract":"<jats:p>\n                    In the present study, eight novel substituted 4\u2010cyano\u2010\n                    <jats:italic>N<\/jats:italic>\n                    \u2010(4\u2010cyano\u20101,3\u2010oxazol\u20105\u2010yl)\u2010\n                    <jats:italic>N<\/jats:italic>\n                    \u2010alkyl\u20101,3\u2010oxazole\u20105\u2010sulfonylamides have been synthesized. Compounds are characterized by IR,\n                    <jats:sup>1<\/jats:sup>\n                    H,\n                    <jats:sup>13<\/jats:sup>\n                    C NMR spectroscopy, elemental analysis, and chromato\u2010mass\u2010spectrometry. The anticancer activities of six compounds are evaluated against the NCI\u201060 human tumor cell line panel. The tested compounds exhibit the strongest antiproliferative (TGI) and cytotoxic (LC\n                    <jats:sub>50<\/jats:sub>\n                    ) activities within the leukemia, non\u2010small\u2010cell lung cancer, melanoma, and colon cancer subpanels. Overall, the mean activity parameters (GI\n                    <jats:sub>50<\/jats:sub>\n                    , TGI, and LC\n                    <jats:sub>50<\/jats:sub>\n                    ) calculated for three compounds do not differ significantly and are within the range of 1\u2013100\u2009\u00b5M, and for some lines, it reaches the value 10\n                    <jats:sup>\u22128<\/jats:sup>\n                    \u2009mol\u2009L\n                    <jats:sup>\u22121<\/jats:sup>\n                    . Structure\u2013activity relationship analysis reveals markedly higher activity for bisoxazole derivatives bearing 4\u2010MeC\n                    <jats:sub>6<\/jats:sub>\n                    H\n                    <jats:sub>4<\/jats:sub>\n                    or 4\u2010FC\n                    <jats:sub>6<\/jats:sub>\n                    H\n                    <jats:sub>4<\/jats:sub>\n                    at the second position of the oxazole rings (compounds\n                    <jats:bold>2<\/jats:bold>\n                    ,\n                    <jats:bold>3<\/jats:bold>\n                    , and\n                    <jats:bold>7<\/jats:bold>\n                    ), whereas derivatives with diphenyl, di\u2010tolyl substituents (compounds\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>6<\/jats:bold>\n                    ), or 4\u2010ClC\n                    <jats:sub>6<\/jats:sub>\n                    H\n                    <jats:sub>4<\/jats:sub>\n                    (compound\n                    <jats:bold>8<\/jats:bold>\n                    ) exhibit substantially lower anticancer activity. In addition, the potential molecular mechanisms of anticancer action of these compounds are investigated using molecular docking methods. Derivatives show the highest affinity for tubulin and cyclin\u2010dependent kinases. Docking of 4\u2010cyano\u2010\n                    <jats:italic>N<\/jats:italic>\n                    \u2010[4\u2010cyano\u20102\u2010(4\u2010fluorophenyl)\u20101,3\u2010oxazol\u20105\u2010yl]\u2010\n                    <jats:italic>N<\/jats:italic>\n                    \u2010methyl\u20102\u2010(4\u2010methylphenyl)\u20101,3\u2010oxazole\u20105\u2010sulfonamide into the colchicine\u2010binding site of \u03b1\u03b2\u2010tubulin reveals a binding affinity of \u221210.9\u2009kcal\u2009mol\n                    <jats:sup>\u22121<\/jats:sup>\n                    , with the ligand located at the subunit interface.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202500921","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T19:59:13Z","timestamp":1764791953000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Synthesis and Anticancer Activity Study of New Bis\u20101,3\u2010Oxazole\u20105\u2010Sulfonylamides"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1517-4807","authenticated-orcid":false,"given":"Maryna","family":"Kachaeva","sequence":"first","affiliation":[{"name":"Department of Chemistry of Bioactive Nitrogen Containing Heterocyclic Bases V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine  1 Academician Kukhar str. Kyiv 02094 Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7089-1393","authenticated-orcid":false,"given":"Stepan","family":"Pilyo","sequence":"additional","affiliation":[{"name":"Department of Chemistry of Bioactive Nitrogen Containing Heterocyclic Bases V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine  1 Academician Kukhar str. Kyiv 02094 Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6161-9833","authenticated-orcid":false,"given":"Diana","family":"Hodyna","sequence":"additional","affiliation":[{"name":"Laboratory of Medical and Biological Research V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine  1 Academician Kukhar str. Kyiv 02094 Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1073-0600","authenticated-orcid":false,"given":"Yurii","family":"Shulha","sequence":"additional","affiliation":[{"name":"Department of Mechanisms of Bioorganic Reactions V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine  1 Academician Kukhar str. Kyiv 02094 Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6668-3412","authenticated-orcid":false,"given":"Volodymyr","family":"Brovarets","sequence":"additional","affiliation":[{"name":"Department of Chemistry of Bioactive Nitrogen Containing Heterocyclic Bases V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine  1 Academician Kukhar str. 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