{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T02:16:28Z","timestamp":1777860988628,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:00:00Z","timestamp":1776556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:00:00Z","timestamp":1776556800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,4,28]]},"abstract":"<jats:p>\n                    A series of acrylamide analogs of rimonabant, where the\n                    <jats:italic>N<\/jats:italic>\n                    \u2010aminopiperidine moiety was replaced by various amines such as benzylamines or heterocyclic amines, were synthesized and their inhibition of nitric oxide (NO) production was evaluated in lipopolysaccharide (LPS)\u2010induced BV2 microglial cells. Among the synthesized compounds, the 3\u2010dimethylaminobenzyl analog\n                    <jats:bold>7n<\/jats:bold>\n                    (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u20091.32\u2009\u00b1\u20090.01\u2009\u03bcM) showed significantly higher inhibitory activity than rimonabant (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u200915.66\u2009\u00b1\u20090.14\u2009\u03bcM) and suppressed NO production dose\u2010dependently without cytotoxicity. In addition,\n                    <jats:bold>7n<\/jats:bold>\n                    inhibited the expression of iNOS, COX\u20102, and proinflammatory cytokines and attenuated LPS\u2010induced activation of nuclear factor\u2010kappa B (NF\u2010\u03baB) and MAPK phosphorylation in BV2 cells. These results demonstrated that\n                    <jats:bold>7n<\/jats:bold>\n                    exerted anti\u2010inflammatory effects by NF\u2010\u03baB and the JNK and p38 MAPK pathways in BV2 cells and could become a prospective candidate for treatment of neuroinflammation\u2010related disorders.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202500938","type":"journal-article","created":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T21:13:47Z","timestamp":1776633227000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis of Acrylamide Analogs of Rimonabant and Evaluation of Anti\u2010Inflammatory Activities by Inhibiting NF\u2010\u03baB and MAPK Signaling Pathways in Lipopolysaccharide\u2010Induced BV2 Cells"],"prefix":"10.1002","volume":"21","author":[{"given":"Sung\u2010Hwa","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Molecular Science and Technology Ajou 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