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An emerging therapeutic strategy toward DM1 treatment relies on the inhibition of MBNL1 sequestration by using small molecules, oligomers, peptides, engineered proteins, or synthetic oligonucleotides that interact with CUG repeats at the RNA level and\/or CTG repeats at the DNA level. This review covers\u2009\u223c18 years of research in the field of CUG and CTG ligands that were identified or rationally designed as DM1 drug candidates, with an emphasis on their chemical structures, molecular design, RNA\u2010 or DNA\u2010binding modes, in vitro affinities and specificities, molecular mechanisms of action, and biological activity in DM1 models.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202500958","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:37:23Z","timestamp":1773049043000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Targeting Expanded CUG and CTG Repeats as a Therapeutic Approach for Myotonic Dystrophy Type 1 (DM1)"],"prefix":"10.1002","volume":"21","author":[{"given":"Camille","family":"Richagneux","sequence":"first","affiliation":[{"name":"CMBC, CNRS UMR9187, INSERM U1196, Institut Curie Universit\u00e9 Paris Saclay  Orsay 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