{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:59:31Z","timestamp":1775869171117,"version":"3.50.1"},"reference-count":64,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"vor","delay-in-days":30,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Described herein are the design, synthesis, and preliminary antimicrobial evaluations of fluorinated pyrrolidine analogs of the potent antiparasitic agents: febrifugine and halofuginone. Molecular modeling is used to confirm that this \u201cisosteric\u201d replacement of a 3\u2010hydroxy with a 3\u2010fluoro group might be well tolerated at the most widely reported molecular target of this compound class, prolyl\u2010tRNA synthetase. The synthesis of the fluorinated analogs is then detailed including the separate preparation of both the\n                    <jats:italic>trans<\/jats:italic>\n                    \u22122,3\u2010 and\n                    <jats:italic>cis<\/jats:italic>\n                    \u22122,3\u2010diastereomeric forms. These synthetic compounds are subsequently assessed for their ability to inhibit the growth of pathogenic fungi (\n                    <jats:italic>C. albicans<\/jats:italic>\n                    and\n                    <jats:italic>F. graminearum<\/jats:italic>\n                    ) and representative Gram\u2010positive and Gram\u2010negative bacteria (\n                    <jats:italic>Bacillus<\/jats:italic>\n                    sp. CS93 and\n                    <jats:italic>E. coli<\/jats:italic>\n                    ). Notably, the 3\u2010fluoro halofuginone analog has anti\u2010\n                    <jats:italic>C. albicans<\/jats:italic>\n                    activity at levels comparable to the natural product iturin A.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202500961","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T20:44:02Z","timestamp":1769892242000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis of Novel Fluorinated Febrifugine Analogs and Evaluation of Their Antifungal Activity"],"prefix":"10.1002","volume":"21","author":[{"given":"Fahad","family":"Alkhathami","sequence":"first","affiliation":[{"name":"Centre for Synthesis and Chemical Biology School of Chemistry University College Dublin  Dublin D04 N2E2 Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Periklis","family":"Karamanis","sequence":"additional","affiliation":[{"name":"Centre for Synthesis and Chemical Biology School of Chemistry University College Dublin  Dublin D04 N2E2 Ireland"},{"name":"Biorbic Bioeconomy SFI Research Centre University College Dublin  Dublin D04 V1W8 Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kacper","family":"Kluza","sequence":"additional","affiliation":[{"name":"Centre for Synthesis and Chemical Biology School of Chemistry University College Dublin  Dublin D04 N2E2 Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Knox","sequence":"additional","affiliation":[{"name":"School of Biological Health and Sports Sciences Faculty of Sciences and Health Technical University Dublin  Dublin D07 XT95 Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0584-876X","authenticated-orcid":false,"given":"Paul","family":"Evans","sequence":"additional","affiliation":[{"name":"Centre for Synthesis and Chemical Biology School of Chemistry University College Dublin  Dublin D04 N2E2 Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3102-2558","authenticated-orcid":false,"given":"Marina","family":"Rubini","sequence":"additional","affiliation":[{"name":"Centre for Synthesis and Chemical Biology School of Chemistry University College Dublin  Dublin D04 N2E2 Ireland"},{"name":"Biorbic Bioeconomy SFI Research Centre University College Dublin  Dublin D04 V1W8 Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.103.2663.59.c"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01199a513"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01186a031"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01185a028"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01171a080"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/161400b0"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo01135a003"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.endeavour.2008.07.001"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118093"},{"key":"e_1_2_7_11_1","first-page":"65","volume":"7","author":"Takeuchi Y.","year":"2001","journal-title":"Trends Het. 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