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Among them, most of 2\u2010aryl(alkyl)benzimidazole hydroxamic acids (\n                    <jats:bold>11<\/jats:bold>\n                    \u2010\n                    <jats:bold>16<\/jats:bold>\n                    ) exhibited HDAC6 activity and slight HDAC1 (or HDAC2) activity. In addition, they also showed anti\u2010angiogenic activity and inhibited the growth of tested cancer cells. For instance, compound\n                    <jats:bold>13<\/jats:bold>\n                    has a GI\n                    <jats:sub>50<\/jats:sub>\n                    of 3.9 \u03bcM against EPCs and inhibited the growth of HCT\u2010116, SK\u2010Hep\u20101, and PC\u20103 cells with GI\n                    <jats:sub>50<\/jats:sub>\n                    values of 1.3, 4.2, and 7.5 \u03bcM, respectively. The exact mechanism underlying the anti\u2010angiogenic effects of these compounds remains unknown, though this study gives an insight into how future HDAC inhibitors that aim to target blood vessel formation can be designed.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202500984","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:40:02Z","timestamp":1777513202000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis of 2\u2010Aryl(alkyl)benzimidazole Hydroxamic Acids as HDAC Inhibitors with Anti\u2010Angiogenesis Properties"],"prefix":"10.1002","volume":"21","author":[{"given":"Yi\u2010Ting","family":"Liu","sequence":"first","affiliation":[{"name":"School of Pharmacy College of Pharmacy, Taipei Medical University  Taipei City 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