{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T14:50:47Z","timestamp":1787928647826,"version":"build-2784847793"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,4,28]]},"abstract":"<jats:p>\n                    <jats:bold>Background and objectives<\/jats:bold>\n                    : Antibiotic resistance is a major global health challenge, driven by misuse in medicine and agriculture and the scarcity of new drugs.\n                    <jats:italic>Allium<\/jats:italic>\n                    \u2010derived organosulfur molecules have shown antimicrobial and synergistic effects with antibiotics. This study aimed to evaluate the in vitro antibacterial activity of four\n                    <jats:italic>Allium<\/jats:italic>\n                    \u2010derived compounds and their potential synergy with clinical antibiotics against multidrug\u2010resistant bacteria.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods<\/jats:bold>\n                    : A total of 330 multidrug\u2010resistant clinical isolates were analyzed, including Gram\u2010positive cocci and Gram\u2010negative bacilli. Antibacterial activity of propyl\u2010propane\u2010thiosulfinate, propyl\u2010propane\u2010thiosulfonate (PTSO), butyl\u2010butane\u2010thiosulfinate, and butyl\u2010butane\u2010thiosulfonate was determined by broth microdilution. Synergy with conventional antibiotics was assessed in 24 representative isolates using the checkerboard method, with interactions classified by the fractional inhibitory concentration index.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : PTSO exhibited the highest activity, with MIC\n                    <jats:sub>50<\/jats:sub>\n                    of 4\u20138\u2009\u00b5g\/mL and MIC\n                    <jats:sub>90<\/jats:sub>\n                    up to 8\u2009\u00b5g\/mL against\n                    <jats:italic>S. aureus<\/jats:italic>\n                    ,\n                    <jats:italic>E. faecalis<\/jats:italic>\n                    , and\n                    <jats:italic>S. agalactiae<\/jats:italic>\n                    . Activity against Gram\u2010negative bacteria was limited, though PTSO was the most active. Checkerboard assays showed predominantly indifferent interactions, but partial synergy with aminoglycosides was observed in both Gram\u2010positive and Gram\u2010negative bacteria.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion<\/jats:bold>\n                    : PTSO demonstrated the most significant activity against multidrug\u2010resistant Gram\u2010positive bacteria, with limited impact on Gram\u2010negative strains, and partial synergy with aminoglycosides suggests a potential role for combination therapy.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202501034","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T14:10:08Z","timestamp":1777299008000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>Allium<\/i>\n                    \u2010Derived Compounds Against Multidrug\u2010Resistant Bacteria: Antibacterial Activity and Synergistic Effects"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0249-2291","authenticated-orcid":false,"given":"Antonio","family":"Sorl\u00f3zano\u2010Puerto","sequence":"first","affiliation":[{"name":"Department of Microbiology Faculty of Medicine University of Granada and Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yariel","family":"Figueroa\u2010Vega","sequence":"additional","affiliation":[{"name":"Department of Microbiology Faculty of Medicine University of Granada and Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Mart\u00edn\u2010Valenzuela","sequence":"additional","affiliation":[{"name":"Department of Microbiology Faculty of Medicine University of Granada and Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA  Granada 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