{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T06:16:57Z","timestamp":1783577817556,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009139","name":"Deutsches Zentrum f\u00fcr Infektionsforschung","doi-asserted-by":"publisher","award":["TTU\u201009.921"],"award-info":[{"award-number":["TTU\u201009.921"]}],"id":[{"id":"10.13039\/100009139","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,4,14]]},"abstract":"<jats:p>\n                    Biofilm\u2010associated infections caused by\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (\n                    <jats:italic>S. aureus<\/jats:italic>\n                    ) remain notoriously difficult to treat due to their pronounced tolerance to most antibiotics. Here, we evaluated the antibiofilm efficacy of the natural product antibiotic corallopyronin A (CorA) across a panel of strains, including clinically relevant strains differing in their biofilm\u2010forming capacities and antibiotic resistance profiles. CorA is an alpha\u2010pyrone antibiotic produced by\n                    <jats:italic>Corallococcus coralloides<\/jats:italic>\n                    . It targets the switch region of the bacterial DNA\u2010dependent RNA polymerase, thereby blocking transcription initiation at a site distinct from the rifampicin\u2010binding pocket, and displays potent activity against staphylococci, including MRSA and rifampicin\u2010resistant\n                    <jats:italic>S. aureus<\/jats:italic>\n                    . In vitro, CorA eradicated and inhibited biofilm formation, outperforming the biofilm\u2010active antibiotics dalbavancin and rifampicin both in optical density measurements and in microscopic analyses. Importantly, CorA had activity against rifampicin\u2010resistant strains in these assays. In a murine foreign body infection model with\n                    <jats:italic>S. aureus<\/jats:italic>\n                    SA113, CorA treatment resulted in\n                    <jats:italic>a<\/jats:italic>\n                    \u2009&gt;\u20094\u2010\n                    <jats:italic>log<\/jats:italic>\n                    <jats:sub>10<\/jats:sub>\n                    reduction in bacterial loads on implanted devices and surrounding tissues, comparable with high\u2010dose rifampicin, and significantly reduced local inflammation. These findings position CorA as a promising candidate for preventing and managing staphylococcal biofilm\u2010associated infections, warranting further investigation into its clinical potential.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202501057","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T05:40:44Z","timestamp":1776231644000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Breaking Down Barriers: CorA Effectively Targets Staphylococcal Biofilms in Vitro and in Vivo"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9284-9623","authenticated-orcid":false,"given":"Stefania","family":"De Benedetti","sequence":"first","affiliation":[{"name":"Institute for Pharmaceutical Microbiology University Hospital Bonn  Bonn Germany"},{"name":"German Centre for Infection Research DZIF Partner site Bonn\u2010Cologne  Bonn 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