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In this study, two new series of hybrid derivatives of 4\u2010amino\u20101,2\u2010naphthoquinones bearing a triazole ring were synthesized via a three\u2010step procedure. These compounds were evaluated for antifungal activity and for their ability to generate reactive oxygen species (ROS). The compounds were active against both yeast and filamentous fungi. Notably, their antifungal effect was not linked to ROS generation or to interaction with lanosterol 14\u03b1\u2010demethylase, the main accepted mechanisms of action for naphthoquinones and triazoles, respectively. 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