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Hydrazone ligands (\n                    <jats:bold>1\u201020<\/jats:bold>\n                    ) were synthesized from ethylcarbazate and salicylaldehyde derivatives and subsequently coordinated with Co(II), Ni(II), Cu(II), and Zn(II) metals. The compounds were structurally characterized through NMR (\n                    <jats:sup>1<\/jats:sup>\n                    H and\n                    <jats:sup>13<\/jats:sup>\n                    C), mass spectrometry, fourier transform infrared (FT\u2010IR), ultraviolet\u2013visible (UV\u2013Vis), scanning electron microscopy, electron spin resonance, powder x\u2010ray diffraction (PXRD), thermogravimetric analysis (TGA), and conductivity studies, revealing an octahedral geometry. Biological activity of the synthesized compounds was analyzed for antimalarial, antioxidant, and antimicrobial properties employing microassay, DPPH radical scavenging and serial dilution method, respectively. In vitro screening of the synthesized compounds for antimalarial and antimicrobial activities revealed that compounds (\n                    <jats:bold>15<\/jats:bold>\n                    ) and (\n                    <jats:bold>16<\/jats:bold>\n                    ) were most active, demonstrating superior IC\n                    <jats:sub>50<\/jats:sub>\n                    values 0.066\u20130.067\u2009\u00b5g\/mL against\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    and (MIC values of 0.0332\u20130.0408\u2009\u03bcmol\/mL against bacterial strain and 0.0087\u2009\u03bcmol\/mL against fungal strain, respectively. The antioxidant assessments showed that complexes\n                    <jats:bold>(<\/jats:bold>\n                    <jats:bold>17<\/jats:bold>\n                    ),\n                    <jats:bold>(<\/jats:bold>\n                    <jats:bold>19)<\/jats:bold>\n                    , and (\n                    <jats:bold>20<\/jats:bold>\n                    ) were the most effective in attenuating oxidative stress, as indicated by their minimal IC\n                    <jats:sub>50<\/jats:sub>\n                    values (3.1\u2009\u00b1\u20090.026\u2009\u03bcM\u20134.2\u2009\u00b1\u20090.0004\u2009\u03bcM). Molecular docking supported the bioactivity, showing higher binding affinities for complexes (\n                    <jats:bold>15<\/jats:bold>\n                    ) and (\n                    <jats:bold>16<\/jats:bold>\n                    ). The compound's oral drug\u2010like structure was confirmed by absorption, distribution, metabolism, excretion, and toxicity (ADMET) analysis.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202501071","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T07:26:27Z","timestamp":1774941987000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bioactive Transition Metal(II) Hydrazone Complexes: Spectral Elucidation, Antimalarial, Antioxidant, and Antimicrobial Activities Correlated With Molecular Docking and Absorption, Distribution, Metabolism, Excretion, and Toxicity"],"prefix":"10.1002","volume":"21","author":[{"given":"Manisha","family":"Rathi","sequence":"first","affiliation":[{"name":"Department of Chemistry Guru Jambheshwar University of Science and Technology  Hisar Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9408-578X","authenticated-orcid":false,"given":"Jai","family":"Devi","sequence":"additional","affiliation":[{"name":"Department of Chemistry Guru Jambheshwar University of Science and Technology  Hisar Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishu","family":"Dhillayan","sequence":"additional","affiliation":[{"name":"Department of Chemistry Guru Jambheshwar University of Science and Technology  Hisar Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonika","family":"Asija","sequence":"additional","affiliation":[{"name":"Department of Chemistry Guru Jambheshwar University of Science and Technology  Hisar Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2025.143570"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-85643-6"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202300326"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.30875\/9789287076717"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202400715"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.7776"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.138604"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.140804"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2017.03.080"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2024.113497"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.139774"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202502737"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/asia.202400676"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.7050"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10847-023-01196-z"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1515\/revic-2024-0007"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2022.134384"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/00958972.2018.1519553"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-024-00593-2"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11164-023-04991-y"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202300158"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/00958972.2025.2495099"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11164-023-05222-0"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2023.111473"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-04073-6"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2024.112585"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.59467\/IJHC.2025.35.245"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rechem.2023.101121"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10904-023-02862-y"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10904-023-02808-4"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202500940"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e16973"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matpr.2021.10.360"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-38086-w"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10973-022-11293-9"},{"key":"e_1_2_11_37_1","first-page":"180","article-title":"Composition 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