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Herein, we present a novel synthetic route to LSD1\u2010targeting compounds that enables late\u2010stage diversification; the key intermediate\n                    <jats:bold>LYY\u201023<\/jats:bold>\n                    was used to synthesize\n                    <jats:bold>CC\u201090011<\/jats:bold>\n                    and\n                    <jats:bold>MS9117<\/jats:bold>\n                    . In addition, compounds\n                    <jats:bold>LYY\u201025 \u223c LYY\u201029<\/jats:bold>\n                    were synthesized and evaluated for LSD1 inhibition, all of which showed inhibitory activity, with\n                    <jats:bold>LYY\u201028<\/jats:bold>\n                    emerging as the most potent compound (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u20093.59\u2009nM).\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202501081","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:19:55Z","timestamp":1772990395000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel Synthetic Route for Lysine\u2010Specific Demethylase 1\u2010Targeting Compounds: CC\u201090011 and MS9117"],"prefix":"10.1002","volume":"21","author":[{"given":"Jingying","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of 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