{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T08:07:23Z","timestamp":1783843643884,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021T140739"],"award-info":[{"award-number":["2021T140739"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,3,27]]},"abstract":"<jats:p>\n                    In the search for new CDDOs (2\u2010cyano\u20103,12\u2010dioxooleana\u20101,9(11)\u2010dien\u201028\u2010oic acid derivatives) with higher antitumor activity in vivo, thirty CDDO\u2010imidazole derivatives (\n                    <jats:bold>1\u201330<\/jats:bold>\n                    ) were designed and synthesized. Then,\n                    <jats:bold>8<\/jats:bold>\n                    was selected due to its superior anti\u2010proliferative activity against three cancer cell lines (B16F10, A549, and HCT116) and its lower toxicity in zebrafish embryos compared to the other evaluated compounds. Further study found that\n                    <jats:bold>8<\/jats:bold>\n                    induced apoptosis in HCT116 cells by downregulating Bcl\u20102, upregulating Bax, and activating caspase\u20103 to kill cancer cells. Notably,\n                    <jats:bold>8<\/jats:bold>\n                    exhibited significant antitumor efficacy comparable to CDDO\u2010Me (bardoxolone methyl), which had entered clinical trials. Taken together,\n                    <jats:bold>8<\/jats:bold>\n                    represents a promising candidate for the treatment of cancer and merits further study.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202600008","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T07:30:47Z","timestamp":1774942247000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Discovery of New CDDO\u2010Imidazole Derivatives as Potential Antitumor Agents"],"prefix":"10.1002","volume":"21","author":[{"given":"Yanqing","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key 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