{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T02:16:19Z","timestamp":1777860979544,"version":"3.51.4"},"reference-count":86,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003185","name":"Fraunhofer Society","doi-asserted-by":"publisher","award":["178\u2013600040"],"award-info":[{"award-number":["178\u2013600040"]}],"id":[{"id":"10.13039\/501100003185","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,4,28]]},"abstract":"<jats:p>\n                    Manganese\u2010based contrast agents (MBCAs) are promising alternatives to currently used gadolinium\u2010based contrast agents (GBCAs) for magnetic resonance imaging (MRI). This study describes the synthesis and physicochemical evaluation of two new zwitterionic Mn(III) porphyrin chelates (\n                    <jats:bold>Mn\u20108<\/jats:bold>\n                    and\n                    <jats:bold>Mn\u20109<\/jats:bold>\n                    ). Both compounds were synthesized\n                    <jats:italic>via<\/jats:italic>\n                    copper\u2010catalyzed azide\u2013alkyne cycloaddition (CuAAC) from an azido\u2010substituted precursor. Both zwitterionic compounds are soluble in water and are remarkably stable to acidic pH and transmetallation under challenging conditions. The complexes have a high\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    \u2010relaxivity, comparable to current clinical high\u2010relaxivity GBCAs like gadopiclenol. In addition, zwitterionic complexes\n                    <jats:bold>Mn\u20108<\/jats:bold>\n                    and\n                    <jats:bold>Mn\u20109<\/jats:bold>\n                    have superior relaxivity and improved stability compared to Mn\u2010DPDP (mangafodipir, Teslascan). The favorable properties of both compounds can be attributed to the decoration of the chelator with sulfobetaines or\n                    <jats:italic>N<\/jats:italic>\n                    \u2010oxides. Importantly, chelation of Mn(III) by the porphyrin drastically reduces singlet oxygen generation.\n                    <jats:bold>Mn\u20108<\/jats:bold>\n                    showed good contrast enhancement in vivo. These compounds are thus strong candidates for the development of next\u2010generation gadolinium\u2010free MRI contrast agents.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.70268","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T07:49:55Z","timestamp":1776325795000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Zwitterionic Mn(III)\u2010Tetraphenyl Porphyrins: Water\u2010Soluble MRI Contrast Agents with High Relaxivity"],"prefix":"10.1002","volume":"21","author":[{"given":"Darius","family":"Ludolfs","sequence":"first","affiliation":[{"name":"Department of Chemistry Institute of Pharmacy Universit\u00e4t Hamburg  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lennart F. 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