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Tazarotene (TZE), a third\u2010generation retinoid and prodrug, is converted in the skin to its active form, tazarotenic acid (TZA). Its structure allows absorption of UVA\/UVB light, prompting concerns about potential phototoxicity, but data on the excited state properties of TZE and TZA are still lacking. This work investigates these retinoids\u2019 behavior under UVA light exposure through a combined spectroscopic, analytical, and biological approximation. The results show that both compounds form long\u2010lived triplet excited states, which interact with oxygen to produce reactive singlet oxygen. Additionally, TZA interacts with tryptophan (Trp), leading to the formation of a photoproduct with a mass corresponding to a Trp\/TZA cyclobutene adduct. These results correlate with reduced cell viability in fibroblasts exposed to light after treatment with TZE or TZA, indicating potential phototoxic effects. 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